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Nutrition, Vitamins & Supplements for Seniors

Protection from cardiovascular disease found in red wine, a senior favorite

Resveratrol binds with KSRP regulator protein to activate anti-inflammatory effect

Red wine being poured into a glassDec. 4, 2014 Reports on the health benefits of coffee and wine are always popular with senior citizens and this latest on red wine is a zinger. A natural substance present in red wine, resveratrol, inhibits the formation of inflammatory factors that trigger cardiovascular diseases.

Cardiovascular disorders, such as myocardial infarction (heart attack) and strokes, frequently occur in association with chronic inflammatory diseases, such as arthritis, which is common among senior citizens. The natural substance resveratrol thus has major therapeutic potential, particularly when it comes to the treatment of inflammatory diseases that can cause serious damage to the cardiovascular system.

The results have recently been published in the scientific journal Nucleic Acids Research.

 

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This finding has been established by a research team at the Department of Pharmacology of the University Medical Center of Johannes Gutenberg University of Mainz (JGU) working in collaboration with researchers of the Friedrich Schiller University in Jena and the University of Vienna.

"We now know more precisely how resveratrol inhibits the formation of the inflammatory factors that trigger cardiovascular diseases. This is an important finding in view of the fact that more recent research has shown that cardiovascular diseases are significantly promoted by inflammatory processes in the body," said Junior Professor Andrea Pautz of the Mainz University Medical Center, who made the discovery with Professor Hartmut Kleinert following collaboration in a joint project with Professor Oliver Werz of the Friedrich Schiller University and Professor Verena Dirsch of the University of Vienna.

Despite the fact that they eat more fatty foods, the French tend to less frequently develop cardiac diseases than Germans. This so-called French Paradox is attributed to the higher consumption of red wine in France and it has already been the subject of various studies in the past.

A number of research projects have actually demonstrated that the natural product resveratrol, present in red wine, has a protective effect against cardiovascular diseases. But what exactly is the reason for this? It seems that at least part of the protective effect can be explained by the fact that resveratrol inhibits the formation of inflammatory factors.

In fact, these researchers discovered that the natural substance binds to the regulator protein KSRP and activates it. KSRP reduces the stability of messenger RNA (mRNA) in connection with a number of inflammatory mediators and thus inhibits their blending together.

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