Chemical in Coffee Appears to Prevent Weight Gain,
Previous studies have shown that
coffee consumption may lower the risk for chronic diseases
14, 2014 Senior citizens are delighted to hear good things about their
favorite drink coffee and it seems to just keep on coming. The
latest is research that has found a chemical compound commonly found in
coffee may help prevent some of the damaging effects of obesity and
prevents weight gain.
Researchers at the University of
Georgia report in Pharmaceutical Research that chlorogenic acid,
or CGA, significantly reduced insulin resistance and accumulation of fat
in the livers of mice who were fed a high-fat diet.
"Previous studies have shown that
coffee consumption may lower the risk for chronic diseases like Type 2
diabetes and cardiovascular disease," said Yongjie Ma, a postdoctoral
research associate in UGA's College of Pharmacy and lead author of the
"Our study expands on this
research by looking at the benefits associated with this specific
compound, which is found in great abundance in coffee, but also in other
fruits and vegetables like apples, pears, tomatoes and blueberries."
During the past 20 years, there has
been a dramatic increase in obesity in the United States. More than
one-third of U.S. adults and approximately 17 percent of children are
obese, according to the Centers for Disease Control and Prevention, and
the annual medical cost of obesity is more than $147 billion.
Aside from weight gain, two common
side effects of obesity are increased insulin resistance and the
accumulation of fat in the liver. Left untreated, these disorders can
lead to diabetes and poor liver function.
To test the therapeutic effects of
CGA, researchers fed a group of mice a high-fat diet for 15 weeks while
also injecting them with a CGA solution twice per week.
They found that CGA was not only
effective in preventing weight gain, but it also helped maintain normal
blood sugar levels and healthy liver composition.
"CGA is a powerful antioxidant that
reduces inflammation," said Ma, who works in the laboratory of professor
Dexi Liu in the department of pharmaceutical and biomedical sciences. "A
lot of evidence suggests that obesity-related diseases are caused by
chronic inflammation, so if we can control that, we can hopefully offset
some of the negative effects of excessive weight gain."
But the authors are quick to point
out that CGA is not a cure-all. Proper diet and regular exercise are
still the best methods to reduce the risks associated with obesity.
The mice in this study received a
high dose of CGA, much higher than what a human would absorb through
regular coffee consumption or a diet rich in fruits and vegetables.
However, the researchers do believe
that CGA may form the foundation of a treatment for those who need extra
help. They plan to conduct more research to develop an improved CGA
formulation specifically for human consumption.
"We're not suggesting that people
start drinking a lot of coffee to protect themselves from an unhealthy
lifestyle," said Ma, who is also a member of UGA's Obesity Initiative.
"But we do think that we might be
able to create a useful therapeutic using CGA that will help those at
risk for obesity-related disease as they make positive lifestyle
Research in this article was
supported in part by grants from the National Institutes of Health.
Good news may warrant changes to current heart failure prevention guidelines of American Heart Association that say coffee drinking
may be risky for heart patients; bit of bad news - excess coffee bad! -
June 27, 2012
Positive impact of caffeine on cognition and memory
performance, other benefits of caffeine in special supplement to the
Journal of Alzheimer's Disease - (Amsterdam) May 17, 2010
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