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Nutrition, Vitamins & Supplements for Seniors

Seniors’ favorite drink wins again: four or more cups of coffee a day puts brakes on prostate cancer

Researchers see very big drop in this cancer for heavy coffee drinkers, but no drop in deaths; also find dangers for some men

Aug. 26, 2013 – The good news continues for the favorite drink of senior citizens. A new study found that men who drank four or more cups of coffee per day experienced a 59 percent reduced risk of prostate cancer recurrence and/or progression as compared to those who drank only one or fewer cups per week.

They did not, however, find an association between coffee drinking and reduced mortality from prostate cancer, although the study by Fred Hutchinson Cancer Research Center scientists included too few men who died of prostate cancer to address that issue separately.

Corresponding author Janet L. Stanford, Ph.D., co-director of the Program in Prostate Cancer Research in the Fred Hutch Public Health Sciences Division, conducted the study to determine whether the bioactive compounds in coffee and tea may prevent prostate cancer recurrence and delay progression of the disease.

The work of Stanford and colleagues is online ahead of print in Cancer Causes & Control.

First study to assess the link between tea and prostate cancer outcomes

Regarding tea consumption, the researchers did not find an associated reduction of prostate cancer recurrence and/or progression. The study also did not draw any conclusions regarding the impact of tea drinking on prostate-specific death.

“To our knowledge, our study is the first to investigate the potential association between tea consumption and prostate cancer outcomes,” the authors wrote.

“It is important to note, however, that few patients in our cohort were regular tea drinkers and the highest category of tea consumption was one or more cups per day. The association should be investigated in future studies that have access to larger populations with higher levels of tea consumption.”

The population-based study involved 1,001 prostate cancer survivors, aged 35-74 years old at the time of diagnosis (between 2002-2005), who were residents of King County, Wash.

 

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More Links to Archived Stories on Coffee Below


Read more on Nutrition, Vitamins & Supplements

 

Participants answered questions regarding their diet and beverage consumption two years prior to prostate cancer diagnosis using a validated food frequency questionnaire, and were interviewed about demographic and lifestyle information, family history of cancer, medication use and prostate cancer screening history.

The researchers followed up with patients more than five years after diagnosis to ascertain whether the prostate cancer had recurred and/or progressed. Those who were still living, willing to be contacted and had been diagnosed with non-metastatic cancer were included in the follow-up effort.

Of the original 1,001 patients in the cohort, 630 answered questions regarding coffee intake, fit the follow-up criteria and were included in the final analysis. Of those, 61 percent of the men consumed at least one cup of coffee per day and 12 percent consumed the highest amount: four or more cups per day.

The study also evaluated daily coffee consumption in relation to prostate cancer-specific death in 894 patients using data from the initial food frequency questionnaire. After the median follow-up period of eight-and-a-half years, 125 of the men had died, including 38 specifically from prostate cancer. Daily coffee consumption was not associated with prostate cancer-specific mortality or other-cause mortality, but with few deaths these analyses were limited.

“Our study differs from previous ones because we used a composite definition of prostate cancer recurrence/progression,” said first author Milan Geybels, a doctoral student at Maastricht University in the Netherlands who was a graduate student in Stanford’s Prostate Studies group at Fred Hutch when the study was conducted.

“We used detailed information on follow-up prostate-specific antigen levels, use of secondary treatment for prostate cancer and data from scans and biopsies to assess occurrence of metastases and cause-specific mortality during follow up. Using these detailed data, we could determine whether a patient had evidence of prostate cancer recurrence or progression.”

The results are consistent with findings from Harvard’s Health Professionals Follow-up Study, which found that men who drank six or more cups of coffee per day had a 60 percent decreased risk of metastatic/lethal prostate cancer as compared to coffee abstainers.

Phytochemicals in coffee have anti-inflammatory and antioxidant effects

Further research is required to understand the mechanisms underlying the results of the study, but biological activities associated with consumption of phytochemical compounds found in coffee include anti-inflammatory and antioxidant effects and modulation of glucose metabolism. These naturally occurring compounds include:

    Caffeine, which has properties that inhibit cell growth and encourage apoptosis, or programmed cell death. Previous studies have found that caffeine consumption may reduce the risk of several cancer types, including basal-cell carcinoma, glioma (a cancer of the brain and central nervous system) and ovarian cancer.

    Diterpenes cafestol and kahweol, which may inhibit cancer growth.

    Chlorogenic acid, which, along with caffeic acid, can inhibit DNA methylation, a biochemical process involved in the development and progression of many cancer types.

Additional studies needed to confirm whether coffee can prevent cancer recurrence

The researchers emphasize that coffee or specific coffee components cannot be recommended for secondary prevention of prostate cancer before the preventive effect has been demonstrated in a randomized clinical trial. Further, there’s ongoing debate about which components in coffee are anti-carcinogenic, and additional large, prospective studies are needed to confirm whether coffee intake is beneficial for secondary prevention.

Coffee not always a safe drink for all men

Coffee drinking may even be problematic for some men, Geybels said.

“Although coffee is a commonly consumed beverage, we have to point out that increasing one’s coffee intake may be harmful for some men. For instance, men with hypertension may be vulnerable to the adverse effects of caffeine in coffee. Or, specific components in coffee may raise serum cholesterol levels, posing a possible threat to coronary health. Patients who have questions or concerns about their coffee intake should discuss them with their general practitioner,” he said.

Most Adults Won’t Give Up Sex to Stay Young, Senior Citizens Won’t Give Up Coffee

April 20, 2004

The investigators also noted limits to their study, which included a lack of data on how coffee consumption might have changed following diagnosis, whether the coffee that participants consumed was caffeinated or decaffeinated, and how the coffee was prepared (espresso, boiled or filtered), a factor that may affect the bioactive properties of the brew.

The National Cancer Institute, Fred Hutchinson Cancer Research Center, Prostate Cancer Foundation and Dutch Cancer Society funded the research.

Notes:

At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Private contributions are essential for enabling Fred Hutch scientists to explore novel research opportunities that lead to important medical breakthroughs. For more information visit www.fredhutch.org or follow Fred Hutch on Facebook, Twitter or YouTube.

Links to More Archived Stories About Coffee

Does Coffee Deserve Credit for Boom in Senior Citizen Population?

Massive study declares coffee drinkers have lower risk of death; seniors have declared coffee more important that sex - see video - May 17, 2012


Coffee Antioxidant Properties May Protect Women Against Uterine Cancer

Drinking more than four cups of coffee daily cut risk by 25%; coffee fast-emerging as protective against a number of diseases- see video - Nov. 28, 2011


Coffee, Favorite Drink of Seniors, Provides Protection from Basal Cell Carcinoma

Women get almost twice as much protection as men among 3-cup a day drinkers - see video - Oct. 26, 2011


Older Women See Depressions Go Down as Coffee Drinking Goes Up

Depression is chronic and recurring condition affecting twice as many women as men; includes about 1 of every 5 U.S. women - Sept. 26, 2011


Coffee Drinking Fights Off Prostate and Breast Cancer: Happy Older Americans Month

Senior citizens say they will give up sex before coffee; must be delighted with latest news on how it protects both sexes from most prominent cancers

May 19, 2011


More Evidence that Coffee Protects from Diabetes; Caffeine Probably the Cause

Encouraging news for seniors who are major targets of diabetes and love coffee

June 8, 2010


New Study Says Caffeine Slows Alzheimer's, Other Dementias, Restores Cognitive Function

Positive impact of caffeine on cognition and memory performance, other benefits of caffeine in special supplement to the Journal of Alzheimer's Disease - (Amsterdam) May 17, 2010


Regular Coffee, Decaf and Tea All Associated With Reduced Risk of Type 2 Diabetes

Info more than doubled since coffee first linked to reducing diabetes risk; unlikely just related to caffeine

Dec. 14, 2009


Favorite Drink of Senior Citizens, Coffee Appears to Fight Advanced Prostate Cancer

More good news for senior men is FDA consideration of prostate cancer vaccine, Provenge

Dec. 8, 2009


Caffeine Miraculously Restores Memory in Old Mice with Alzheimer’s Disease Symptoms

Coffee, the favorite drink of senior citizens, sure to get more popular with discovery of the memory recovery power of five cups a day that reduces beta-amyloid protein in blood

July 6, 2009


Good News for Seniors: Coffee Kills Pain When You Exercise, May Help Performance, Too

But does that reduction in pain translate into an improvement in sport performance?

April 1, 2009


Older Women Lower Stroke Risk by Drinking Coffee Frequently and Not Smoking

It only works for healthy women but two cups a day does the trick; unfortunately, many heavy coffee drinkers tend to smoke

Feb. 17, 2009


Seniors Will Appreciate Study Finding Coffee Drinkers Less Likely to Get Alzheimer’s in Old Age

Drinking 3-5 cups per day shows best results – lowers Alzheimer’s risk by 65%

Jan. 28, 2009


Women Drinking Large Amounts of Coffee May Lower Their Risk of Death

Study finds coffee drinkers – caffeinated and decaf - with slightly lower death rates; men about even

June 17, 2008 - Video link in story


Chemists Say They Now Know How to Remove Bitterness from Coffee

Great news for senior citizens who already prefer coffee to sex

Aug. 22, 2007


Older Women Who Drink Three Cups of Coffee Daily Protect Memory

Caffeine appears to reduce cognitive decline, but not in men

Aug. 7, 2007


Drinking Coffee May Offer Senior Men Protection from Gout Arthritis

Something in coffee lowers uric acid levels in blood - May 25, 2007


Senior Citizens Drinking Lots of Caffeine Lower Risk of Heart Disease Death

No significant protective effect in patients below the age of 65 - Feb. 23, 2007


Senior Citizens Find Surprisingly ‘Good News’ in 30 Years of Coffee Research

'Many negative health myths about coffee drinking may now be transformed into validated health benefits' - Jan. 22, 2007


Most Adults Won’t Give Up Sex for Staying Young, Senior Citizens Won’t Give Up Coffee

April 20, 2004


Adding Sugar to Your Coffee Could Lead to Pancreatic Cancer

Adding sugar to food or drinks five times a day increases risk 70% - Nov. 8, 2006


Senior Coffee Addicts Who Choose Decaf to Avoid Caffeine May Be in for a Jolt

October 11, 2006


Coffee Drinking Associated with Lower Risk for Alcohol-Related Liver Disease

June 13, 2006


Even Excessive Coffee Drinking Does Not Increase Risk of Coronary Heart Disease

April 25, 2006


Is Coffee the Solution to Everything from Cancer to Female Sex Drive?

Jan. 18, 2006

More Coffee Benefits (Science Daily)

New Evidence That Drinking Coffee May Reduce the Risk of Diabetes (June 10, 2010) — Scientists are reporting new evidence that drinking coffee may help prevent diabetes and that caffeine may be the ingredient largely responsible for this ... > read more

Coffee Consumption Associated With Reduced Risk of Advanced Prostate Cancer (Dec. 8, 2009) — While it is too early for physicians to start advising their male patients to take up the habit of regular coffee drinking, new data revealed a strong inverse association between coffee consumption ... > read more

Higher Coffee Consumption Associated With Lower Liver Cancer Risk (June 27, 2008) — A new large, prospective population-based study confirms an inverse relationship between coffee consumption and liver cancer risk. The study also found that higher levels of gamma-glutamyltransferase ... > read more

Coffee Drinking Related To Reduced Risk Of Liver Cancer (Aug. 2, 2007) — A new study on the relationship between coffee drinking and the risk of liver cancer (hepatocellular carcinoma) confirmed that there is an inverse association between coffee consumption and HCC, ... > read more

 

 

 

 

 

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