Trans Fat Increases Stroke Risk in Older Women; Aspirin Reduces Risk in Study
Those who ate the most trans fat were 66% more likely to have an ischemic stroke
March 1, 2012 -Older women whose diets include a substantial amount of trans fats are more likely than their counterparts
to suffer an ischemic stroke, a new study shows. However, the risk of stroke associated with trans fat intake was lower among women taking
aspirin, according to the findings from University of North Carolina at Chapel Hill researchers.
The report, "Trans Fat Intake, Aspirin and Ischemic Stroke Among Postmenopausal Women," was published today online in the
journal Annals of Neurology.
The study of 87,025 generally healthy postmenopausal women aged 50 to 79 found that those whose diets contained the
largest amounts of trans fats were 39 percent more likely to have an ischemic stroke (clots in vessels supplying blood to the brain) than
women who ate the least amount of trans fat.
The risk was even more pronounced among non-users of aspirin: those who ate the most trans fat were 66 percent more
likely to have an ischemic stroke than females who ate the least trans fat.
However, among women who took aspirin over an extended period of time, researchers found no association between trans fat
consumption and stroke risk suggesting that regular aspirin use may counteract trans fat intake's adverse effect on stroke risk among women.
Trans fat is generally created in the food production process and is found in commercially prepared foods, including many
shortenings, cake mixes, fried fast foods, commercially baked products (such as doughnuts, cakes and pies), chips, cookies and cereals.
Researchers from the UNC Gillings School of Global Public Health studied women who were enrolled in the Women's Health
Initiative Observational Study. From 1994 to 2005, 1,049 new cases of ischemic stroke were documented.
Women who consumed the highest amount of trans fat also were more likely to be smokers, have diabetes, be physically
inactive and have lower socioeconomic status than those who consumed the least trans fat, the study showed.
"Our findings were contrary to at least two other large studies of ischemic stroke," said Ka He, Sc.D., M.D., associate
professor of nutrition and epidemiology at the UNC public health school. "However, ours was a larger study and included twice as many cases of
ischemic stroke. Our unique study base of older women may have increased our ability to detect the association between trans fat intake and
ischemic stroke among non-users of aspirin."
He said aspirin may lower the risk of ischemic stroke because of its anti-inflammatory and anti-platelet clumping
The UNC researchers did not find any association between eating other kinds of fat (including saturated, monounsaturated
or polyunsaturated fat) and ischemic strokes.
"Our findings highlight the importance of limiting the amount of dietary trans fat intake and using aspirin for primary
ischemic stroke prevention among women, especially among postmenopausal women who have elevated risk of ischemic stroke," said lead author
Sirin Yaemsiri, a doctoral student in the school's epidemiology department.
Along with He and Yaemsiri, the study's other authors were Souvik Sen, M.D., professor of neurology at the University of
South Carolina School of Medicine; Lesley Tinker, Ph.D., at the Fred Hutchinson Cancer Research Center in Seattle, Wash.; Wayne Rosamond,
Ph.D., professor of epidemiology at the UNC Gillings School of Global Public Health; and Sylvia Wassertheil-Smoller, Ph.D., professor of
epidemiology and population health at the Albert Einstein College of Medicine in New York.
The new study was supported by a grant from the National Institute of Neurological Disorders and Stroke, one of the
National Institutes of Health. The Women's Health Initiative program is funded by the National Heart, Lung and Blood Institute, also part of
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