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Nutrition, Vitamins & Supplements for Seniors

Vitamin D Does Not Deter Cancer Deaths but Does Reduce Colon Cancer Risk

Highly hyped vitamin D takes a blow from massive study but not dead yet

Oct. 30, 2007 – Vitamin D has received considerable favorable attention lately, primarily as a way to stop cancer, but that came crashing down today with the release of a large study – 16,818 participants – that concluded a higher vitamin D level is not associated with a lower risk of drying from cancer. But wait, the hype is not totally dead – this study did conclude that D substantially decreases the risk of colorectal cancer.

 

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Read more on Nutrition, Vitamins & Supplements

 

Several epidemiological studies have supported the hypothesis that that vitamin D can reduce cancer mortality by decreasing cancer incidence or improving survival. Animal and cell studies suggest that vitamin D may reduce tumor growth and induce cancer cell death. Diet and exposure to sunlight are the major sources of vitamin D.

D. Michal Freedman, Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues analyzed data from the third national Health and Nutrition Examination Survey to examine the relationship between levels of circulating vitamin D in the blood and cancer mortality in a group of 16,818 participants aged 17 and older.

After about a decade of follow-up, 536 participants had died of cancer.

Cancer mortality was not related to the level of circulating vitamin D for the overall group, nor was it related when the researchers looked at the data by sex, race, or age. But higher levels of vitamin D (80 nmol/L or more) were associated with a 72 percent reduced risk of colorectal cancer mortality, compared with lower levels (less than 50 nmol/L).

“To our knowledge, this study is the first to examine the relationship between measured serum vitamin D levels and cancer mortality for selected site and for all sites combined,” the authors write.

In an accompanying editorial, Cindy Davis, Ph.D., and Johanna Dwyer, D.Sc. of the National Institutes of Health in Bethesda, Md., discuss the complicated relationship between nutrients, like vitamin D, and cancer. They suggest that not enough is known about the benefits and limitations of vitamin D to use it for the prevention of disease or death.

“These findings must be put into the context of total diet and lifestyle. There are many risk factors other than diet for colorectal cancer, and there are many possible dietary risk factors other than vitamin D that have been linked to cancer risk,” the editorialists write.

The study was published online October 30 in the Journal of the National Cancer Institute, which is not associated with the U.S. government’s National Cancer Institute.

Source:

Article: Freedman DM, Looker AC, Chang S-C, Graubard BI. Prospective Study of Serum Vitamin D and Cancer Mortality in the United States. J Natl Cancer Inst 2007; 99:1594-1602

Editorial: Davis CD, Dwyer JT. The “Sunshine Vitamin”: Benefits Beyond Bone" J Natl Cancer Inst 2007; 99:1563-1565


How others are reporting it today…

Vitamin D May Not Lower Cancer Deaths

By LAURAN NEERGAARD

WASHINGTON (AP) — A large new study found no sign that vitamin D lowers the overall risk of dying from cancer, injecting a note of caution to the latest vitamin craze.

The exception: People with more vitamin D in their blood did have a significantly lower risk of death from colorectal cancer, supporting earlier findings.

>> More from Associated Press

Vitamin D cuts colon cancer death risk

Updated Tue. Oct. 30 2007 4:37 PM ET

People with higher vitamin D levels in their blood are less likely to die of colorectal cancer, U.S. researchers said Tuesday.

But the researchers also made the surprising discovery that the vitamin did not appear to affect the chances of dying from any other type of cancer.

The study's results question the conclusions of several other recent studies that have found that vitamin D can lower the risk for many types of cancer. The Canadian Cancer Society was so impressed by the growing body of evidence about the health benefits of vitamin D that it recommended earlier this year that the entire adult population of Canada begin taking vitamin D supplements.

>> More at CTV.ca

Vitamin D No Magic Bullet for Cancer

No Impact on Cancer Death, New Research Suggests

OPINION by LEN LICHTENFELD, M.D.

We have been bombarded over the last couple of years with scientific articles suggesting that vitamin D is the key to improving many aspects of our health, including reducing the risks of dying from cancer.

An article in this week's Journal of the National Cancer Institute reminds us that perhaps we should be a bit cautious in embracing vitamin D as "the answer" before we do more research.

The report, from the National Cancer Institute and the Centers for Disease Control and Prevention, concluded that vitamin D levels in the blood were not related to overall cancer mortality.

However, the study did find that higher levels of vitamin D were associated with a substantial decrease in the risk of dying from colorectal cancer, and possibly with a reduction in the risk of dying from breast cancer.

>> More from ABC News

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