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Nutrition, Vitamins & Supplements for Seniors
Vitamin D Does Not Deter Cancer Deaths but Does
Reduce Colon Cancer Risk
Highly hyped vitamin D takes a blow from massive
study but not dead yet
Oct. 30, 2007 Vitamin D has received considerable
favorable attention lately, primarily as a way to stop cancer, but that
came crashing down today with the release of a large study 16,818
participants that concluded a higher vitamin D level is not associated
with a lower risk of drying from cancer. But wait, the hype is not
totally dead this study did conclude that D substantially decreases
the risk of colorectal cancer.
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Several epidemiological studies have supported the
hypothesis that that vitamin D can reduce cancer mortality by decreasing
cancer incidence or improving survival. Animal and cell studies suggest
that vitamin D may reduce tumor growth and induce cancer cell death.
Diet and exposure to sunlight are the major sources of vitamin D.
D. Michal Freedman, Ph.D., of the National Cancer
Institute in Bethesda, Md., and colleagues analyzed data from the third
national Health and Nutrition Examination Survey to examine the
relationship between levels of circulating vitamin D in the blood and
cancer mortality in a group of 16,818 participants aged 17 and older.
After about a decade of follow-up, 536 participants
had died of cancer.
Cancer mortality was not related to the level of
circulating vitamin D for the overall group, nor was it related when the
researchers looked at the data by sex, race, or age. But higher levels
of vitamin D (80 nmol/L or more) were associated with a 72 percent
reduced risk of colorectal cancer mortality, compared with lower levels
(less than 50 nmol/L).
To our knowledge, this study is the first to
examine the relationship between measured serum vitamin D levels and
cancer mortality for selected site and for all sites combined, the
authors write.
In an accompanying editorial, Cindy Davis, Ph.D.,
and Johanna Dwyer, D.Sc. of the National Institutes of Health in
Bethesda, Md., discuss the complicated relationship between nutrients,
like vitamin D, and cancer. They suggest that not enough is known about
the benefits and limitations of vitamin D to use it for the prevention
of disease or death.
These findings must be put into the context of
total diet and lifestyle. There are many risk factors other than diet
for colorectal cancer, and there are many possible dietary risk factors
other than vitamin D that have been linked to cancer risk, the
editorialists write.
The study was published online October 30 in the
Journal of the National Cancer Institute, which is not associated with
the U.S. governments National Cancer Institute.
Source:
Article: Freedman DM, Looker AC, Chang S-C,
Graubard BI. Prospective Study of Serum Vitamin D and Cancer Mortality
in the United States. J Natl Cancer Inst 2007; 99:1594-1602
Editorial: Davis CD, Dwyer JT. The Sunshine
Vitamin: Benefits Beyond Bone" J Natl Cancer Inst 2007; 99:1563-1565
How others are reporting it today
Vitamin D May Not Lower Cancer Deaths
By LAURAN NEERGAARD
WASHINGTON (AP) A large new study found no sign
that vitamin D lowers the overall risk of dying from cancer, injecting a
note of caution to the latest vitamin craze.
The exception: People with more vitamin D in their
blood did have a significantly lower risk of death from colorectal
cancer, supporting earlier findings.
>>
More from Associated Press
Vitamin D cuts colon cancer death risk
Updated Tue. Oct. 30 2007 4:37 PM ET
People with higher vitamin D levels in their blood
are less likely to die of colorectal cancer, U.S. researchers said
Tuesday.
But the researchers also made the surprising
discovery that the vitamin did not appear to affect the chances of dying
from any other type of cancer.
The study's results question the conclusions of
several other recent studies that have found that vitamin D can lower
the risk for many types of cancer. The Canadian Cancer Society was so
impressed by the growing body of evidence about the health benefits of
vitamin D that it recommended earlier this year that the entire adult
population of Canada begin taking vitamin D supplements.
>>
More at CTV.ca
Vitamin D No Magic Bullet for Cancer
No Impact on Cancer Death, New Research Suggests
OPINION by LEN LICHTENFELD, M.D.
We have been bombarded over the last couple of
years with scientific articles suggesting that vitamin D is the key to
improving many aspects of our health, including reducing the risks of
dying from cancer.
An article in this week's Journal of the National
Cancer Institute reminds us that perhaps we should be a bit cautious in
embracing vitamin D as "the answer" before we do more research.
The report, from the National Cancer Institute and
the Centers for Disease Control and Prevention, concluded that vitamin D
levels in the blood were not related to overall cancer mortality.
However, the study did find that higher levels of
vitamin D were associated with a substantial decrease in the risk of
dying from colorectal cancer, and possibly with a reduction in the risk
of dying from breast cancer.
>>
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