SeniorJournal.com - Daily News for Senior Citizens

  FRONT PAGE Aging • Health • Alzheimer's - Mental • Nutrition • Medicare & Medicaid Politics  • Fitness  • Social Security • Alerts • Sex Health • Features • Retirement  Elder Care  >Search  >Senior Links

 

Health and Medicine for Seniors

Old Lungs Look New Again - Ibuprofen Reduces Inflammation in Elderly

Finding might someday support use of ibuprofen as adjunct therapy for senior citizens with tuberculosis

By Emily Caldwell

lung x-rayOct. 2, 2014 - New research shows that the lungs become more inflammatory from cell damage with age and that ibuprofen can lower that inflammation. Researchers have found that immune cells from old mouse lungs fought tuberculosis bacteria as effectively as cells from young mice after lung inflammation was reduced by ibuprofen.

Most previous research establishing inflammation’s links to aging and disease has tested blood for elevated proteins that signal an inflammatory environment. These researchers found the same proteins in the lungs of old mice. Research has already established that the inevitable inflammation that comes with aging is linked to such conditions as Type 2 diabetes and heart disease.

This was a rare look at inflammation in the aging lung environment by Ohio State University scientists who study the immune response to tuberculosis (TB). The researchers already knew that old mice had a harder time clearing TB from the lungs than young mice, but had not investigated the role of lung inflammation in that response.

They found ibuprofen had no effect on the immune response to TB in young mice.

“Very few researchers have linked inflammation to infectious disease in old age, even though TB in particular will drive that inflammation even further,” said Joanne Turner, associate professor of microbial infection and immunity at Ohio State and senior author of the study.

 

Related Archive Stories

 
 

Seniors are 90% of Flu Deaths; Just 65% Get Free Medicare Vaccinations

Actions those senior citizens 65 and older need to take this flu season with links to lots of information - CDC says get shot by October

Sept. 28, 2014

Diabetes Appears to be Leveling Off in U.S.

Prevalence continues to increase for some subgroups, like young adults; incidence rate up for Hispanic, black adults

Sept. 23, 2014

Lung Cancer Diagnosis Tool Found Safe, Effective for Senior Citizens

Correct assessment of the stage of a patient's cancer – how much tumor has grown and spread – is key to ensuring they receive the right treatment

Aug. 4, 2014

New Long-Term Treatment for COPD Approved by FDA

One of nation’s biggest killers is most often found in senior citizens, current or former smokers, women

July 31, 2014

Read the latest news
> Health & Medicine
>
Today's Headlines

 

“The inflammation-associated changes that we saw in the lung were a small finding, but an important finding because the implications are great,” Turner said. “We should be able to modify the environment in the lung. If we can reverse the inflammatory environment in a very straightforward way that is a positive.”

The research is published in the Journal of Leukocyte Biology.

Though this line of work might someday support the use of ibuprofen as an adjunct therapy for elderly people with TB, Turner emphasized that she and colleagues are not recommending use of the drug for the purposes of lowering inflammation.

“You can actually reduce your inflammation as you age by being lean, eating well and exercising. And we know that in the elderly, people who are fitter live longer,” she said. “Inflammation is associated with sickness and frailty.”

Though the research was conducted in mice, Turner co-led a previous study indicating that both mouse and human lungs develop the same profile of pro-inflammatory proteins and fatty molecules with age, creating an environment that impairs the immune response to infection.

More than 9 million people worldwide are estimated to have active TB infections, and about 1.4 million people die of tuberculosis each year.

“The elderly are most likely to die of TB. They get sicker. They’re not the biggest population that gets infected with TB, but they can develop the worst cases,” said Turner, also an associate director of Ohio State’s Center for Microbial Interface Biology (CMIB).

In this new study, the researchers compared lung cells from old and young mice and found that in the old mice, genes that make three classic pro-inflammatory proteins, called cytokines, were more active in the lungs of old mice. The cytokines are interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a).

In addition, immune system cells called macrophages in the lungs from old mice were in an advanced state of readiness to fight an infection – a status that signals inflammation. Macrophages in young mouse lungs were in a normal, resting state.

In test tubes, the scientists exposed mouse lung macrophages to TB bacteria. The macrophages from old mouse lungs were quicker to absorb the bacteria than were immune cells from young mice, but that initial robust immune response from the cells of old mice could not be sustained.

“A primed macrophage in an old mouse has lots of receptors on its surface that can bind to TB, taking it up and trying to kill it. But what it lacks is the ability to increase the response further,” Turner said. “A resting macrophage in a young mouse takes up TB and then can be activated to do something even more effective at killing the bacteria.”

Though some elements of the elderly response to TB remain a mystery, this finding suggested that the inflammation in the lungs of elderly mice had the direct effect of reducing the long-term effectiveness of their immune response to TB infection, Turner said.

Old mice in the study were 18 months old – equivalent to about 65 in human years – and young mice were 3 months old, a similar age to human young adults.

The researchers gave old and young mice ibuprofen in their food for two weeks and then examined their lung cells. After this diet modification, several pro-inflammatory cytokines in the lungs of old mice had been reduced to levels identical to those in the lungs of young mice, and the macrophages in old mouse lungs were no longer in a primed state.

“There’s a trend toward reduced inflammation. Essentially, ibuprofen made the lungs of old mice look young. Putting young mice on ibuprofen had no effect because they had no lung inflammation, which implies the ibuprofen reduced the inflammation and changed the immune response in the old mice,” Turner said.

“It might be that ibuprofen works on specific pathways to lower inflammation, and that might help with control of TB.”

Turner and colleagues have extended the work to test whether ibuprofen affects the elderly mouse immune response to TB infection.

This work was supported by a Julie Martin Mid-Career Award from the American Federation for Aging Research, the Ohio State University Public Health Preparedness for Infectious Diseases Pilot Award and Ohio State’s College of Medicine Systems and Integrative Biology Training Program.

Co-authors include Cynthia Canan, Nandan Gokhale (now at Duke University), Bridget Carruthers (now with Ohio State’s Office of Environmental Health and Safety), William Lafuse, Larry Schlesinger and Jordi Torrelles, all of Ohio State’s Department of Microbial Infection and Immunity and CMIB.

 

Financial Relief for Volkswagen Diesel Owners

You may be eligible for money damages if you owned or leased one of these VW, Porsche or Audi vehicles.

In the major scandal of 2015, Volkswagen cheated you and the world. They rigged diesel emission controls so you, nor regulators, would know how much pollution their cars were adding to our environment.

They were caught and have reserved $7.3 billion to help "make it right" with victims.

If you owned or leased one of these vehicles, contact us now.

 Beth Janicek, Board Certified Personal Injury Attorney Janicek Law attorneys are actively pursuing these cases against VW. Do Not Wait...

Janicek Law Firm, PC

Free Consultation

(Call toll free)

1-877-795-3425 or Email

Vehicles Involved

VW Jetta (2009–2015)

VW Jetta SportWagen (2009–2014)

VW Golf (2010-2015)

VW Golf SportWagen (2015)

VW Beetle (2012–2015)

VW Passat (2012-2015)

Audi A3 (2010-2015)

VW Touareg (2009–2016)

Porsche Cayenne (2015)

Audi A6, A7, A8, Q5 Quattro (2016)

 

Search for more about this topic on SeniorJournal.com

Google Web SeniorJournal.com
 

Keep up with the latest news for senior citizens, baby boomers

Click to More Senior News on the Front Page

Copyright: SeniorJournal.com

 

 

 

Published by New Tech Media - www.NewTechMedia.com

Other New Tech Media sites include CaroleSutherland.com, BethJanicek.com, SASeniors.com, DrugDanger.com, etc.