Close Relatives of Thyroid Cancer Victims Have
Siblings of those diagnosed with PTC had the highest
risk of developing the cancer
4, 2013 - People that have a first- through
third -degree relative diagnosed with papillary thyroid cancer (PTC)
have an increased risk of developing it themselves, according to a study
by Gretchen M. Oakley M.D., of the University of Utah School of
Medicine, Salt Lake City, and colleagues.
To define the family risk, researchers examined
4,460 patients diagnosed with PTC between 1966 and 2011 at a tertiary
care facility in Utah, using the Utah Population Database to access
medical records and the Utah Cancer registry.
According to study results, first-, second- and
third-degree relatives of PTC study subjects had an increased risk of
developing the cancer in comparison with population controls.
Siblings of those diagnosed with PTC had the
highest risk of developing the cancer (6.8-fold increased risk),
followed by first-degree relatives of patients (5.4-fold increased
risk), and second- and third-degree relatives (2.2-fold and 1.8-fold
increased risk), respectively. There was no significant increased risk
observed in spouses of PTC-diagnosed patients.
These findings also indicate that family members
of known PTC probands [patients used as genetic starting points for the
study] will likely benefit from closer clinical attention, including
collecting and maintaining a three-generation family history.
Translational studies are needed to better define the genetic
predisposition to familial PTC and development and implementation of
optimal screening approaches the study concludes.
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