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Health & Medicine for Senior Citizens

New Early Detection Urine Test for Prostate Cancer Introduced at U. Michigan

Test incorporates three specific markers that could indicate cancer and studies have shown that the combination is far more accurate than PSA alone

Arul Chinnaiyan stands behind Scott Tomlins who is holding up a slide

Arul Chinnaiyan, M.D., Ph.D., and Scott Tomlins, M.D., Ph.D.

Sept. 26, 2013 - More than 1 million men will undergo a prostate biopsy this year, but only about one-fifth of those biopsies will result in a cancer diagnosis. The reason is that the traditional prostate cancer screening test – a blood test to measure prostate specific antigen, or PSA – does not give doctors a complete picture.

Now, the University of Michigan Health System has begun offering a new urine test called Mi-Prostate Score to improve on PSA screening for prostate cancer. The test incorporates three specific markers that could indicate cancer and studies have shown that the combination is far more accurate than PSA alone.

“Many more men have elevated PSA than actually have cancer but it can be difficult to determine this without biopsy. We need new tools to help patients and doctors make better decisions about what to do if serum PSA is elevated. Mi-Prostate Score helps with this,” says Scott Tomlins, M.D., Ph.D., assistant professor of pathology and urology at the University of Michigan.

Researchers validated the new test on nearly 2,000 urine samples. Mi-Prostate Score, or MiPS, was significantly more accurate than PSA alone for predicting cancer as well as predicting aggressive prostate cancer that is likely to grow and spread quickly.

 

Related Archive Stories

 
 

Most Older Men Say They Want Prostate Cancer Test Despite Risks, Task Force Objections

Although experts say middle-aged men should not have routine PSA tests, majority of older men disagree, especially those of higher income, black or had recent test - July 11, 2013

Evidence Grows that Observation is Safe, Cost Effective for Low-Risk Prostate Cancer Patients

Study focused on men age 65 to 75 when diagnosed; 70% of prostate cancer is low-risk, but 60% of these get treatment - June 18, 2013

More news about prostate cancer below news story.


 
 

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Mi-Prostate Score developed from a discovery in the lab of Arul Chinnaiyan, M.D., Ph.D., in 2005 of a genetic anomaly that occurs in about half of all prostate cancers, an instance of two genes changing places and fusing together.

This gene fusion, T2:ERG, is believed to cause prostate cancer. Studies in prostate tissues show that the gene fusion almost always indicates cancer. 

The new urine test looks for the T2:ERG fusion as well as another marker, PCA3. This is combined with serum PSA measure to produce a risk assessment for prostate cancer. The test also predicts risk for having an aggressive tumor, helping doctors and patients make decisions about whether to wait and monitor test levels or pursue immediate biopsy.

“This combination test is not designed to say definitively at diagnosis whether a man has aggressive prostate cancer, but it can provide a more accurate estimate of the likelihood of having cancer and the likelihood of that cancer being aggressive,” Tomlins says.

The test is available to anyone but requires a request from a doctor. For further information, call the University of Michigan’s MLabs at 800-862-7284.

Prostate cancer statistics: 238,590 Americans will be diagnosed with prostate cancer this year and 29,720 will die from the disease, according to the American Cancer Society

Disclosure: The University of Michigan has been issued a patent on the detection of ETS gene fusions in prostate cancer, on which Tomlins and Chinnaiyan are listed as co-inventors. The diagnostic field of use has been licensed to Hologic. Chinnaiyan has served as a consultant to Hologic.  

>> More at the University of Michigan on Prostate Cancer Screening Methods


More SeniorJournal.com news on Prostate Cancer

Latest Prostatectomy Radiation Treatment – IMRT – Not More Effective for Senior Citizens

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May 21, 2013

New Prostate Cancer Test Better at Determining Candidates for Surveillance

UC San Francisco tool billed as better at determining risk; could save many at low-risk from treatment that is now common

May 8, 2013

New Guidelines Urge Older Men Discuss Benefits, Harms of Prostate Cancer Screening with Doctor

American Urological Association changes position to slow wide-spread screening for men 55 to 69; opposes routine screening of men 40 to 50; no screening if 70+

May 3, 2013

Men Who Take Statins Less Likely to Die from Prostate Cancer

Statins prescribed as drugs to control cholesterol but may work against number one cancer killer of men

May 2, 2013

Almost Half of Deaths from Prostate Cancer Can Be Predicted by PSA Before Men Reach Age 50

Earlier 2010 study in BMJ showed PSA level at age 60 is strongly predictive of the risk of death from prostate cancer by age 85

April 17, 2013

Men with Lynch Syndrome Genetic Condition at Greater Risk of Prostate, Other Cancers

New study adds prostate to list of several cancers associated with one of the most common inherited cancer conditions

April 1, 2013

Prostate Screening Tests In Older Men Decline, But Many Still Get Them, Study Finds

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By Julie Appleby, CAPSULES: Short Takes On News & Events - March 4, 2013

Large Study Shows Elderly and African-American Men at Increased Risk of Having Aggressive Prostate Cancer

This cancer only found by PSA testing but not known if early detection and treatment can be beneficial

Feb. 13, 2013

Prostate Cancer Survivors Differ in Side Effects by Treatment, But It Evens Out After 15 Years: All See Sexual, Urinary Decline

All aggressive therapies for prostate cancer have significant side effects and perhaps these data make an argument for active surveillance (avoiding aggressive treatment and closely following the cancer) in certain cases

Jan. 30, 2013

 

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