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Health & Medicine for Senior Citizens

Women with Uterine Cancer Reduce Death Risk by 84 Percent with Statin and Aspirin

Even those just using a statin saw 45% decline in risk of dying; disease usually targets older women

June 3, 2013 – Endometrial (more commonly called uterine cancer) patients who took statins and aspirin reduced their chance of death by a highly significant 84 percent, according to a new study by researchers at Montefiore Einstein Center for Cancer Care. More than half of women diagnosed with endometrial cancer are in the 50-69 age group.

Additionally, women who used only statins saw their risk of dying decline by 45 percent. The study was presented Monday at the annual meeting of the American Society of Clinical Oncology in Chicago.

 

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Endometrial cancer is the most common cancer of the female reproductive organs and includes several types of malignancies that appear in the lining of the uterus. The American Cancer Society estimates nearly 50,000 new cases of endometrial cancer will be diagnosed in the United States this year, and more than 8,100 women will die from it.

“These data are important as we explore the use of statins in patients with conditions beyond cardiovascular disease,” said lead author Nicole Nevadunsky, M.D., gynecologic oncologist, MECCC and Assistant Professor, Department of Obstetrics & Gynecology and Women's Health, Albert Einstein College of Medicine of Yeshiva University.

“We were pleased by these results and are continuing our efforts to understand the unexpected positive effects of these medications in endometrial cancer.”

About Uterine Cancer (Also called: Endometrial cancer)

MedlinePlus

The uterus, or womb, is an important female reproductive organ. It is the place where a baby grows when a women is pregnant. There are different types of uterine cancer. The most common type starts in the endometrium, the lining of the uterus. This type of cancer is sometimes called endometrial cancer.

The symptoms of uterine cancer include

   ● Unusual vaginal bleeding or discharge

   ● Trouble urinating

   ● Pelvic pain

   ● Pain during intercourse

Uterine cancer usually occurs after menopause. Being obese and taking estrogen-alone hormone replacement therapy (also called menopausal hormone therapy) also increase your risk. Treatment varies depending on your overall health, how advanced the cancer is and whether hormones affect its growth. Treatment is usually a hysterectomy, which is surgery to remove the uterus. The ovaries and fallopian tubes are also removed. Other options include hormone therapy and radiation.

NIH: National Cancer Institute

This retrospective study analyzed medical records of 554 patients diagnosed with endometrial cancer between January 2005 and December 2009. Among them, 165 patients were on statin therapy and 68 women were taking both statins and aspirin. All patients were treated at Montefiore Medical Center.

“It is not uncommon for women in their 50s and 60s to take statins and aspirin to treat cardiovascular conditions like high cholesterol or hypertension," says Dr. Nevadunsky.

"Given the clear association we saw between statin and aspirin use and improved cancer survival, further evaluation is warranted to help us better understand how these medications may improve survival in endometrial and other cancers.”

In addition to Dr. Nevadunsky, the research team from Montefiore and Einstein included Lori Spoozak, M.D., Eugenia Girda, M.D., Anne Van Arsdale, M.D., Mark H. Einstein, M.D. and Gary L. Goldberg, M.D.

About Montefiore Medical Center
As the University Hospital for Albert Einstein College of Medicine, Montefiore is a premier academic medical center nationally renowned for its clinical excellence, scientific discovery and commitment to its community. For more information visit www.montefiore.org.

 

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