Women with Uterine Cancer Reduce Death Risk by 84
Percent with Statin and Aspirin
Even those just using a statin saw 45% decline in
risk of dying; disease usually targets older women
June 3, 2013 Endometrial (more commonly called
uterine cancer) patients who took statins and aspirin reduced their
chance of death by a highly significant 84 percent, according to a new
study by researchers at
Montefiore Einstein Center for
Cancer Care. More than half of women diagnosed with
endometrial cancer are in the 50-69 age group.
Additionally, women who used only statins saw their
risk of dying decline by 45 percent. The study was presented Monday at
the annual meeting of the American Society of Clinical Oncology in
Endometrial cancer is the most common cancer of the
female reproductive organs and includes several types of malignancies
that appear in the lining of the uterus. The American Cancer Society
estimates nearly 50,000 new cases of endometrial cancer will be
diagnosed in the United States this year, and more than 8,100 women will
die from it.
These data are important as we explore the use of
statins in patients with conditions beyond cardiovascular disease, said
lead author Nicole Nevadunsky, M.D., gynecologic oncologist, MECCC and
Assistant Professor, Department of Obstetrics & Gynecology and Women's
Albert Einstein College of Medicine
of Yeshiva University.
We were pleased by these results and are
continuing our efforts to understand the unexpected positive effects of
these medications in endometrial cancer.
About Uterine Cancer (Also
called: Endometrial cancer)
The uterus, or womb,
is an important female reproductive organ. It is the place where
a baby grows when a women is pregnant. There are different types
of uterine cancer. The most common type starts in the
endometrium, the lining of the uterus. This type of cancer is
sometimes called endometrial cancer.
The symptoms of
uterine cancer include
● Unusual vaginal
bleeding or discharge
● Pelvic pain
● Pain during
usually occurs after menopause. Being obese and taking
estrogen-alone hormone replacement therapy (also called
menopausal hormone therapy) also increase your risk. Treatment
varies depending on your overall health, how advanced the cancer
is and whether hormones affect its growth. Treatment is usually
which is surgery to remove the uterus. The ovaries and fallopian
tubes are also removed. Other options include hormone therapy
This retrospective study analyzed medical records
of 554 patients diagnosed with endometrial cancer between January 2005
and December 2009. Among them, 165 patients were on statin therapy and
68 women were taking both statins and aspirin. All patients were treated
at Montefiore Medical Center.
It is not uncommon for women in their 50s and 60s
to take statins and aspirin to treat cardiovascular conditions like high
cholesterol or hypertension," says Dr. Nevadunsky.
"Given the clear association we saw between statin
and aspirin use and improved cancer survival, further evaluation is
warranted to help us better understand how these medications may improve
survival in endometrial and other cancers.
In addition to Dr. Nevadunsky, the research team
from Montefiore and Einstein included Lori Spoozak, M.D., Eugenia Girda,
M.D., Anne Van Arsdale, M.D., Mark H. Einstein, M.D. and Gary L.
About Montefiore Medical Center As the University Hospital for Albert Einstein College of Medicine,
Montefiore is a premier academic medical center nationally renowned for
its clinical excellence, scientific discovery and commitment to its
community. For more information visit
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