Robotic Bladder Cancer Surgery Safer, Less Invasive But More Costly
One in 100 receiving open radical cystectomy died during hospitalization, no in-hospital deaths for robotic-assisted
cystectomy; fourth leading cancer for men
2, 2012 - With technological advancements opening the door to less invasive medical procedures, robotic-assisted surgery is becoming
increasingly popular, despite being more expensive than traditional surgery. Robotic-assisted surgical removal of the bladder due to cancer is
a new approach to the traditional "open" or more invasive operation called a radical cystectomy.
Bladder cancer is the fourth most commonly diagnosed cancer in men, and the American Cancer Society estimates that 73,500
people will be diagnosed with bladder cancer in 2012 . A third of those will require a radical cystectomy. It is also estimated there will be
14,880 deaths from the disease.
During a robotic procedure, the surgeon sits behind a console several feet from the patient and uses joysticks and foot
peddles to control a robot; the robot holds and manipulates small surgical tools, which are inserted through tiny key-hole incisions in the
Previously noted benefits of robotic surgery include smaller incisions and less trauma for the patient.
In addition, surgeons have a better three-dimensional view and more freedom of wrist movement, and the procedure
eliminates hand tremors, making tasks like suturing easier.
But since the robotic surgery field is fairly new, only now are larger, more comprehensive studies being published that
compare hospital and patient outcomes of traditional open surgeries to robot-assisted procedures.
A new study currently online in the journal European Urology has found that compared to open surgery for bladder
cancer, robotic surgery results in fewer deaths and in-patient complications and reduces the need for intravenous nutrition after the
procedure. The procedure, however, is more costly.
"While we expected to see greater expenses associated with the robotic procedure for bladder cancer, we were surprised to
see the significant reduction in deaths and complications, particularly this early in its adoption," said the study's senior author, Dr. Jim
Hu, director of minimally invasive surgery in the urology department at the David Geffen School of Medicine at UCLA.
Hu noted that previous reports of outcomes from robotic-assisted surgery have come from single medical centers and have
not included direct comparisons to traditional surgery.
"This is one of the first national population-based studies comparing robotic and traditional surgery outcomes for
bladder cancer," Hu said. It is also one of the first studies to compare the procedures in a variety of hospital settings across the country.
In conducting the research, Hu, along with colleagues at Harvard Medical School and Georgetown University Hospital, used
the U.S. Nationwide Inpatient Sample, a national government database of hospital in-patient information that includes data from 1,050
hospitals in 44 states.
The researchers used information from 2009, the most recent date for which data were available on radical cystectomy for
bladder cancer at the time the study was conducted. The team looked at 1,444 traditional open surgeries and 224 robotic-assisted laparoscopic
procedures. They found that robotic-assisted surgeries accounted for 13 percent of all radical cystectomies in 2009.
Using statistical analysis, Hu and his colleagues compared hospital-level information, including in-patient deaths,
complications, length of hospital stays and costs for the two procedures.
One of the most striking findings the team reported was that one in 100 patients receiving open radical cystectomy (2.5
percent) died during hospitalization, but there were no in-hospital deaths for patients who underwent robotic-assisted cystectomy.
The researchers also found that patients who underwent robotic-assisted laparoscopic surgery experienced fewer in-patient
complications than those who had the traditional open procedure (49.1 percent vs. 63.8 percent).
After the robotic procedure, patients also had less need of parenteral nutrition than their open-surgery counterparts
(6.4 percent vs. 13.3); parenteral nutrition is provided intravenously if there is delayed recovery of bowel function.
The researchers found no difference in the length of hospital stays between the two procedures, with patients who
underwent both types of surgery spending approximately eight days in the hospital.
Total costs for the robotic procedure, however, were significantly higher more than $3,000 higher than traditional open
surgery. The researchers said this may be due to longer operation
times and greater use of disposable instruments with the robot. Hu also noted that the study didn't factor in expenses
for robot acquisition and maintenance, so the costs may be even higher.
In addition, women were less likely to undergo a robotic procedure, possibly due to gender-based differences in anatomy
that make robotic procedures more difficult, the researchers said. Bladder cancer is rarer in women men are three times more likely to be
diagnosed with the disease.
The researchers found that 95.7 percent of the robotic procedures compared with 73.9 percent of traditional procedures
were performed at teaching hospitals.
The majority of both types of patients (76.8 percent for the robotic procedure and 67 percent for the open procedure) had
key lymph nodes removed during their operations, in keeping with a national practice guideline related to reducing disease recurrence and
improving survival. Still, roughly a quarter of robotic-procedure patients and a third of open-procedure patients did not undergo lymph node
removal, indicating that both procedures could improve in this area.
Hu noted that while the surgeon plays the most important role in bladder cancer surgery outcomes, better tools may help
the surgeon achieve improved outcomes. Just as newer tennis rackets made of synthetic fibers cost more but allow greater precision and power
than the wooden rackets of 40 years ago, robotic surgery for bladder cancer has certain advantages over the traditional open approach.
"The history of most technology demonstrates that as more innovations and advances occur over time, the costs may be
reduced," Hu said. "We hope that our study will add to the growing base of outcomes information in the robotics field."
Hu said the next stage of research will involve expanding the study to follow patients beyond the hospital. The team will
also look more closely at the severity of surgical complications, assess tumor characteristics and include other factors that may play a role
The researchers suggest that interested patients ask their doctors if they are candidates for robotic-assisted bladder
cancer surgery and make sure to obtain second opinions to gauge the confidence, training and experience of the surgeons.
The study was funded by the American Urological Association Foundation and the U.S. Department of Defense.
Additional study authors included Dr. Hua-yin Yu and Dr. Adam S. Kibel, Division of Urology, Brigham and Women's
Hospital, Harvard Medical School, Boston; Nathanael D. Hevelone and Stuart R. Lipsitz, Center for Surgery and Public Health, Brigham and
Women's Hospital, Harvard Medical School, Boston; Dr. Keith J. Kowalczyk, Department of Urology,
Georgetown University Hospital, Washington, D.C.; Dr. Paul L. Nguyen, Department of Radiation Oncology, Lank Center for
Genitourinary Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston; and Dr. Toni K. Choueiri, Department of Medicine, Lank
Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston.
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