March 15, 2012 - Women 65 or older who have even mild retinopathy, a disease of blood vessels in the retina, are more
likely to have cognitive decline and related vascular changes in the brain, according to a multi-institutional study led by scientists at the
University of California, San Francisco (UCSF).
The findings suggest that a relatively simple eye screening could serve as a marker for cognitive changes related to
vascular disease, allowing for early diagnosis and treatment, potentially reducing the progression of cognitive impairment to dementia.
As retinopathy usually is caused by Type II diabetes or hypertension, a diagnosis could indicate early stages of these
diseases, before they are clinically detectable. Early diagnosis could allow for lifestyle or drug interventions when they might be most
“Lots of people who are pre-diabetic or pre-hypertensive develop retinopathy,” said the lead author of the study,
Mary Haan, DrPH, MPH, UCSF professor of epidemiology and biostatistics. “Early intervention might reduce
the progression to full onset diabetes or hypertension.”
The results, reported in the March 14, 2012, online issue of Neurology, were based on data from the Women’s Health
Initiative Memory Study and the Site Examination study, two ancillary studies of the Women’s Health Initiative Clinical Trial of Hormone
In the study, the team followed 511 women with an average starting age of 69, for 10 years. Each year, the women took a
cognition test focused on short-term memory and thinking processes. In the fourth year, they received an exam to assess eye health. In the
eighth year, they received a brain scan.
Of the full group of women, 39 women, or 7.6 percent, were diagnosed with retinopathy. On average, these women scored
worse on the cognition test than the other women. They had more difficulty, for instance, recalling a list of several words five minutes after
The women with retinopathy also had more damage to the blood vessels of the brain. They had 47 percent more ischemic
lesions, or holes, in the vasculature overall and 68 percent more lesions in the parietal lobe. The lesions, associated with vascular disease
and sometimes stroke, are believed to be caused by high blood pressure. They also had more thickening of the white matter tracks that transmit
signals in the brain, which also appear to be caused by high blood pressure.
Notably, the women did not have more brain atrophy, which is associated with Alzheimer’s disease. This result indicates
that retinopathy is a marker of neurovascular disease rather than Alzheimer’s disease, according to Haan.
Co-author Mark A. Espeland, PhD, of Wake Forest University School of Medicine conducted the analysis of the data. The
senior author of the study is
Kristine Yaffe, MD, UCSF professor of psychiatry, neurology and epidemiology and biostatistics.
Other co-authors are Ramon Casanova, PhD, Sarah A. Gaussoin, MS, and Sally A. Shumaker, PhD, of Wake Forest University
School of Medicine; Barbara E. Klein, MD, MPH, of the University of Wisconsin, Madison; Rebecca D. Jackson, MD, of the Ohio State University
Medical Center, Amy E. Millen, PhD, of the State University of New York at Buffalo, Susan M. Resnick, PhD, of the National Institute on Aging,
Jacques E. Rossouw, MD, of the National Heart, Lung and Blood Institute, and Robert Wallace, MD, of the University of Iowa College of
The study was supported by the National Heart, Lung and Blood Institute, the U.S. Department of Health and Human
Services, Wyeth Pharmaceuticals, and the National Institute on Aging.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level
education in the life sciences and health professions, and excellence in patient care.