Cigarette Smoking Causes More Rapid Cognitive Decline in Older Men, Not Women
Study shows smokers who quit 10 years or more do not show faster cognitive decline
6, 2012 - Cigarette smoking in men especially older men - appears to be the cause of a more rapid cognitive decline, according to
a report published Online First by Archives of General Psychiatry, one of the JAMA/Archives journals.
Smoking is increasingly recognized as a risk factor for dementia in the elderly and the number of dementia cases
worldwide, estimated at 36 million in 2010, is on the rise and is projected to double every 20 years, the authors write in their study
In an earlier report on this study, the authors found smokers compared with nonsmokers to have poorer memory and greater
decline in reasoning over 5 years. They also reported long-term ex-smokers to have better memory and verbal fluency scores than never
Sιverine Sabia, Ph.D., of University College London, and colleagues used the Whitehall II cohort study, which is based on
employees of the British Civil Service.
The authors examined the association between smoking history and cognitive decline in the transition from midlife to old
age. Data were obtained from 5,099 men and 2,137 women in the Whitehall II study, with a mean (average) age of 56 years at the first cognitive
In the current study, researchers analyzed data using six assessments of smoking status over 25 years and three cognitive
assessments over 10 years.
The authors note their analysis presents four key findings.
1. Smoking in men is associated with more rapid cognitive decline than in non-smokers or women.
2. Men who continued to smoke over the follow-up experienced greater decline in all cognitive tests.
3. Men who quit smoking within the 10 years preceding the first cognitive measure were still at risk of greater cognitive
decline, especially in executive function (an umbrella term for various complex cognitive processes involved in achieving a particular goal).
4. Long-term ex-smokers 10 years or more - did not show faster cognitive decline. They were more comparable to
"Finally, our results show that the association between smoking and cognition, particularly at older ages, is likely to
be underestimated owing to higher risk of death and dropout among smokers," the authors comment.
The authors also note that their results show no association between smoking and cognitive decline in women, although the
underlying reasons remain unclear. They suggest one explanation for the sex difference they observed might be the greater quantity of tobacco
smoked by men.
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