- Daily News for Senior Citizens

  FRONT PAGE Aging • Health • Alzheimer's - Mental • Nutrition • Medicare & Medicaid Politics  • Fitness  • Social Security • Alerts • Sex Health • Features • Retirement  Elder Care  >Search  >Senior Links


Senior Journal: Today's News and Information for Senior Citizens & Baby Boomers

More Senior Citizen News and Information Than Any Other Source -

• Go to more on Health & Medicine or More Senior News from on the Front Page


E-mail this page to a friend!

Health & Medicine for Senior Citizens

Drug Approved to Treat Nail Fungus Found to Delay Chemo in Advanced Prostate Cancer

Itraconzole slows prostate cancer progression but has potential of serious side effects

Fungal Nail infection, candidal - 3, 2011 - The oral antifungal drug itraconazole, most commonly used to treat nail fungus, may keep prostate cancer from worsening and delay the need for chemotherapy in men with advanced disease, according to new research from John Hopkins.

Currently, the drug is approved to treat fungal infections in nails and other organs. Serious side effects can include heart failure, and Johns Hopkins researchers caution that itraconazole needs further study before it can be considered for prostate cancer treatment (see warnings below artile).


Related Archive Stories


New Surgery-Free Treatment for Enlarged Prostate Avoids Sexual Dysfunction

Prostatic artery embolization as effective as popular TURP surgical method; more than half of senior men have enlarged prostate; also silodosin a new treatment for prostatitis

May 18, 2011

Rising PSA Levels May Sometimes Lead to Negative Biopsies But Usually Means Cancer

News study shows nearly 70 percent with rising PSA eventually get prostate cancer

May 18, 2011

Avodart Not Cost Effective Way to Prevent Prostate Cancer in Some Men

For average man, dutasteride provides minimal survival benefits, reduction on treatment-related complications does not offset the high costs

Feb. 8, 2011

Study Finds Way to ID Aggressive Prostate Cancers; Save Men from Aggressive Therapy

Many prostate cancer patients treated unnecessarily; vast majority would not become life-threatening, even if left untreated

Feb. 3, 2011

Incontinence Following Radical Prostatectomy Reduced by Behavioral Therapy Program

Editorial writers ask if limited benefits are worth the patient and clinician time and effort; researchers say 'yes' do to significant, durable improvement in incontinence and quality of life, - Jan. 12, 2011

More Links to Archived Reports at Bottom of this Page


Read the latest news
> Health & Medicine
Today's Headlines


Details of the finding, from a clinical trial led by Johns Hopkins experts, are scheduled for presentation on Saturday, June 4 at the 2011 American Society of Clinical Oncology (ASCO) annual meeting.

Identified as a potential anticancer drug after Hopkins scientists scoured a database of more than 3,000 FDA-approved drugs, itraconazole appears to block tumor blood vessel growth - the only drug in its class to do so - much like the anticancer drug bevacizumab (Avastin).

The antifungal also disrupts a key cancer-initiating biological pathway called Hedgehog. Laboratory testing by Johns Hopkins scientist Jun Liu, Ph.D., has shown that human prostate tumors implanted in mice shrink when treated with itraconazole.

"The most effective therapy we have right now for metastatic prostate cancer is hormone therapy, and when it doesn't work, the next step is usually chemotherapy," says Emmanuel Antonarakis, M.D., assistant professor of oncology at the Johns Hopkins Kimmel Cancer Center. In a search for compounds that could put off chemotherapy, the Johns Hopkins team turned to itraconazole.

For the study, patients with prostate cancer that had spread to other organs and did not respond to hormone therapy were randomly assigned to receive low or high doses of itraconazole.

Over 24 weeks of daily treatment with oral itraconazole, the investigators tracked the length of time for each patient's prostate cancer to worsen (called progression-free survival). Evidence of worsening disease was measured by a 25 percent increase in their blood level of prostate specific antigen (PSA), a marker for prostate cancer.

Early in the trial, preliminary analysis of 17 men receiving low doses of itraconazole showed that only two of them (11.8 percent) had stable or declining PSA. Because of the limited response, no further men were given low doses of the drug.

However, 11 of 24 (48.4 percent) men taking high doses of itraconazole had stable or declining PSA levels lasting at least 24 weeks. In addition, nearly a third of men taking the high dose had PSA reductions of 30 percent or more. Metastatic prostate cancer patients receiving no treatment typically would worsen in eight to 12 weeks, according to Antonarakis.

The investigators also found that 12 of 14 men taking high doses of itraconazole had lower levels of circulating tumor cells present in their blood after therapy, compared with their baseline levels.

Seven patients experienced side effects, including low potassium, hypertension and fluid retention, but the problems were resolved with potassium replacement pills, anti-hypertension drugs, and diuretics.

"We also tested whether itraconazole acted as hormone therapy by tracking levels of testosterone and DHEA (a testosterone derivative) in the blood, and we found no reductions of either testosterone or DHEA," says Antonarakis.

"This finding shows that itraconazole is not just another hormone therapy, and has a unique mechanism of action."

Antonarakis and colleagues next plan to examine blood and skin samples taken from study participants specifically to look for levels of proteins linked to tumor blood vessel formation and the Hedgehog pathway.

"With these results, we believe that high-dose itraconazole is worth studying in a larger group of men with advanced prostate cancer," adds Antonarakis.

The clinical trial was funded by the Department of Defense (DoD) Prostate Cancer Research Program, the Commonwealth Foundation for Cancer Research, the David H. Koch Charitable Foundation, a 2009 American Society of Clinical Oncology (ASCO) Young Investigator Award granted to Antonarakis, and the National Institutes of Health/National Cancer Institute.

In addition to Antonarakis, other investigators participating in the research on behalf of the Prostate Cancer Clinical Trials Consortium included Amanda Blackford, Serina King, Anja Frost, Seun Ajiboye, Sushant Kachhap, Michelle Rudek, and Michael Carducci from Johns Hopkins; Elisabeth Heath from the Karmanos Cancer Institute; David Smith from University of Michigan, Ann Arbor; and Dana Rathkopf and Daniel Danila from Memorial Sloan Kettering Cancer Center.

Why is Itraconazole prescribed?

Itraconazole capsules are used to treat fungal infections that begin in the lungs and can spread through the body. Itraconazole capsules are also used to treat fungal infections of the fingernails and/or toenails. Itraconazole oral solution is used to treat yeast infections of the mouth and throat and suspected fungal infections in patients with fever and certain other signs of infection. Itraconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.


Itraconazole can cause congestive heart failure (condition in which the heart cannot pump enough blood through the body). Tell your doctor if you have or have ever had heart failure; a heart attack; an irregular heartbeat; any other type of heart disease; lung, liver, or kidney disease; or any other serious health problem. If you experience any of the following symptoms, stop taking itraconazole and call your doctor immediately: shortness of breath; coughing up white or pink phlegm; weakness; excessive tiredness; fast heartbeat; swelling of the feet, ankles, or legs; and sudden weight gain.

Do not take cisapride (Propulsid), dofetilide (Tikosyn), pimozide (Orap), or quinidine (Quinaglute, Quinidex, others), while taking itraconazole. Taking these medications with itraconazole can cause serious irregular heartbeat.

Talk to your doctor about the risks of taking itraconazole.

>> More at PubMed, U.S. National Library of Medicine

More Links to Archived Reports on Prostate Cancer in

Substantial Improvement in Prostate Cancer PSA Testing Discovered by Genetics Firm

Better results will prevent unnecessary biopsies, catch more cancers, says deCODE

Dec. 16, 2010

Popular Prostate Cancer Staging Does Not Predict Recurrence, Study Finds

Clinical stage was assigned incorrectly in 35.4% of 3,875 men in a multi-institutional national disease registry - Nov. 22, 2010

Aspirin Cuts Death Risk in Half for Prostate Cancer Victims Using Radiation or Surgery

Prior studies have shown anticoagulants like aspirin hinder cancer growth,spread

Oct. 25, 2010

Cholesterol-Lowering Drug Shrinks Enlarged Prostates in Hamsters: Hope for Older Men

Even more effective when combined with drugs approved for treating BPH - watch videos

Oct. 22, 2010 –  Read more, watch videos...

Even Senior Citizens Can Reduce Cancer Risk with Plant-Based Diet, Exercise Says New Study

‘It’s Never Too Late to Lower Your Risk’ is new campaign by American Institute for Cancer Research (see video)

Oct. 21, 2010


Prostate Cancer Victims Should Be Especially Watchful for Precancerous Colon Polyps

Study is first to show that men with prostate cancer are at increased risk of colon cancer – two most common cancers for older men

Oct. 20, 2010

Popular ADT Prostate Cancer Treatment Associated with Bone Decay

'Virtual bone biopsies' may help identify men at risk for fractures after androgen deprivation therapy

Oct. 8, 2010

Older Men with Low Baseline PSA Do Not Benefit from Early Prostate Cancer Detection

Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of death from cancer in men in Western countries

Sept. 13, 2010

Most Men With Just Low-Risk Prostate Cancer Receive Aggressive Treatment

Over 90% of prostate cancers diagnosed before they spread and the 5-year survival rate for these is almost 100%

July 27, 2010

New Study Finds Gene Fusions May be ‘Smoking Gun’ in Prostate Cancer Development

Gene fusion – not the androgen receptor – is the more specific “bad actor” in prostate cancer  - May 21, 2010

Provenge Approved as Vaccine for Advanced Prostate Cancer; Activates Immune System

Survival for Provenge patients was 25.8 months, compared to 21.7 months for those receiving placebo

By staff - April 30, 2010

Prostate Cancer Treatment Choices Vary Based on Type of Specialist Men Choose to See

About half of all men seen just by a urologist; last week the attention was on the type of prostate cancer screening men should pursue - March 9, 2010

Study of Senior Men Finds Similar Results With Open or Laparoscopic Prostate Surgery

Researchers studied almost 6,000 senior citizens, suggest patients be informed about the differences and similarities in expected outcomes, make treatment decisions with an experienced surgeon - Feb. 22, 2010

ADT Therapy for Prostate Cancer Can Increase Heart Risk Factors

Androgen-deprivation therapy (ADT) may increase cardiovascular risk, but unclear whether it’s linked to increased death from heart disease - Feb. 3, 2010

Favorite Drink of Senior Citizens Coffee Appears to Fight Advanced Prostate Cancer

More good news for senior men is FDA consideration of prostate cancer vaccine, Provenge

Dec. 8, 2009

Study Uncovers Key to How ‘Triggering Event’ in Prostate Cancer Occurs

Researchers link hormone androgen to creation of gene fusion in prostate cancer, a major killer of older men; may help learn how other cancers begin

Oct. 29, 2009

Cancer Society Stands Firm: Older Women Need Mammograms, Men Need Advice on Prostate Tests

‘Mammography is effective – mammograms work and women should continue to get them,’ ACS

Oct. 23, 2009

Minimally Invasive Radical Prostatectomy Has Advantages, But Higher Rate of Complications

MIRP, especially with robotic assistance, increased from 1% to 40% of radical prostatectomies from 2001 to 2006,despite limited data on outcomes and costs

Oct. 14, 2009

Study Says Men are Not Adequately Involved in Prostate Cancer Screening Discussions

Another new study finds screened men up to four times more likely to be diagnosed with prostate cancer than unscreened men

Sept. 28, 2009

Keep up with the latest news for senior citizens, baby boomers

Study Shows Seed Implants a Suitable Prostate Cancer Treatment Option for Older Men

Prostate cancer treatment ‘outcomes are impacted by disease-related risk factors but not by age

Aug. 4, 2009

Men Who Delay Radical Treatment of Prostate Cancer Don’t Seem to Worry About It

Men with neurotic personalities and those in poor physical health exhibited more anxiety and distress than others

July 27, 2009

Heavy Alcohol Drinking Spurs High-Grade Prostate Cancer, Stops Prevention by Finasteride

Four or more drinks on 5 or more days per week doubles risk of high-grade prostate cancer

July 13, 2009

Predicting the Return of Prostate Cancer Improved by Results from John Hopkins Study

May also help resolve the debate on when, and in what form, secondary treatments should occur

July 2, 2009

PARP Drugs May Be Miracle Cure for Cancer Suggests Success with Breast, Ovarian, Prostate Cancer

NEJM editorial says PARP inhibitors may point to a new direction for anticancer drugs - watch video

June 25, 2009

Veterans Badly Mistreated for Prostate Cancer at VA Hospital, Reports NY Times

92 of 116 cancer treatments were botched during a six year period at Philadelphia unit

June 22, 2009

Prostate Cancer Test Proven to Offer Early Prediction of Bone Metastasis, Mortality

UCSF Cancer of the Prostate Risk Assessment gives patients and doctors a better way of gauging long-term risks and pinpointing high risk cases.

June 15, 2009

New Blood Test Significantly Increases Accuracy of PSA Screening for Prostate Cancer

Greatly reduces false-positives in prostate cancer screening that often require a biopsy of the gland to check for tumors

May 28, 2009

Men Should Not Give Up on PSA Prostate Cancer Screening, Just Yet

Urologists argue that men should not be swayed from getting the test - it still saves lives

May 13, 2009


Statins Protect Against Prostate Cancer, Erectile Dysfunction and Prostate Enlargement, Mayo Study Finds

Study followed older men 40 to 79 from 1990 to assess urologic outcomes among aging men

April 27, 2009

Elderly Men with Short Life Expectancy Do Not Need Prostate Cancer Screening, Study Shows

U.S. trial shows no early mortality benefit from current annual screening for prostate cancer - watch video, link in story

March 19, 2009

Enough is Enough of Prostate-Specific-Antigen Testing Once Men Reach Age 75

PSA test has decreased prostate cancer deaths but other problems more likely to kill elderly

Feb. 23, 2009

Simple Urine Test May Reveal the Aggressiveness of Your Prostate Cancer

Sarcosine is better indicator of advancing disease than traditional prostate specific antigen test (PSA); it is detected in urine, researchers hopeful simple urine test can be used

Feb. 12, 2009

Artificial Light at Night Contributes to Prostate Cancer and Breast Cancer Say Researchers

Theories for cause: suppression of melatonin production, suppression of immune system, body's biological clock confused between night and day

Feb. 3, 2009

GPS for the Body Sometimes Needed for a Moving Prostate During Radiation Therapy

Prostate can move during a treatment session and can make delivering radiation safely to the tumor a challenge

By Constantine A. Mantz, MD

Jan. 21, 2009

Selenium or Vitamin E to Stop Prostate Cancer May Do More Harm Than Good

National Cancer Institute stops clinical trial from going forward

Oct. 27, 2008

Benign Prostatic Hyperplasia Strikes Up to 90 Percent of Oldest Men, Can Be Life-Threatening

It’s Prostate Health Month and urologist say cancer is not the only thing senior citizens should watch for

Sept. 29, 2008

High Cholesterol Bad for Heart but May Also Increases Prostate Cancer Risk

September both National Prostate Health and National Cholesterol Education Months

Sept. 18, 2008

Common Painkillers Like Aspirin Seem to Lower PSA Level that Predicts Prostate Cancer

Not enough data to say that men who took the medications were less likely to get prostate cancer

Sept. 8, 2008

Height Linked to Prostate Cancer Development, Growth in Review of 58 Studies

‘We speculate that factors that influence height may also influence cancer and height is therefore acting as a marker for the causal factors’

Sept. 3, 2008

Brachytherapy May Be Best Prostate Cancer Treatment Choice for Obese Men

Follows finding that surgery is technically more challenging in overweight men

Aug. 19, 2008

Prostate Screening Bias Against Obese Men Leads to Late Detection, Less Surgical Success

Aggressiveness of obese men's late-detected tumors and that they may be more difficult to remove, is a double whammy for fat guys

Aug. 8, 2008

Task Force Says Men Age 75 and Older Should Not Be Screened for Prostate Cancer

Chances are they will die of something else before the cancer gets them

Aug. 5, 2008

Androgen Deprivation Does Not Improve Survival for Seniors with Prostate Cancer

Conservative management of the disease does a better job, says study

July 8, 2008

Radiation for Cancer Recurrence after Radical Prostatectomy Shows Increased Survival

Provocative evidence that even men with adverse prognostic features may benefit from salvage radiotherapy

June 17, 2008

Older Men With Prostate Cancer at Much Greater Risk of Bone Fractures

Patients should be checked for osteoporosis, particularly if treated with ADT

May 14, 2008


> Medical Malpractice,

> Nursing Home Abuse,

> Personal Injury

Our Experienced Lawyers Can Help

Beth Janicek, Board Certified Personal Injury Attorney"We win because we care, we prepare and we have no fear," Beth Janicek, board certified personal injury attorney


Free Consultation on your case.

Call Now Toll Free


or Send Email

More at our Website



Search for more about this topic on

Google Web

Keep up with the latest news for senior citizens, baby boomers


Click to More Senior News on the Front Page




Published by New Tech Media -

Other New Tech Media sites include,,,, etc.