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Senior Citizen Health & Medicine

Senior Citizen Disease that Inflames Arteries in Head Found to Increase Risk of Blindness

Giant cells that destroy bacteria often found in temporal arterities that usually hits at age 70, can lead to Polymyalgia rheumatica

June 17, 2008 – A disease that usually strikes people at about age 70 – temporal arteritis – has been found to increase by three the chance these senior citizens will go blind. And, those with “Giant cells” are three times more likely to develop Polymyalgia rheumatica.

 

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Temporal arteritis, a type of connective tissue disease characterized by inflammation of arteries in the head, can cause headaches, jaw soreness and flu-like symptoms. In this disease, arteries swell and restrict blood flow to the brain. Untreated, the disease can lead to stroke and blindness.

(More about these disease below news report.)

In a study published in a recent edition of the Journal of Clinical Pathology, Geisinger Health System researchers examined the disorder.

Giant cells, which are white blood cells that destroy bacteria, are often found in patients with the disease. The Geisinger study found that patients with giant cells are far more prone to blindness compared to patients without these cells.

The study also found that patients with giant cells are three times more likely to experience Polymyalgia rheumatica, an inflammatory disorder that causes muscle aches and stiffness primarily in the arms, thighs and neck.

"We need to learn more about how these giant cells work so we can limit the effects of this disease, which can cause significant problems if ignored," said Geisinger rheumatologist and lead study author Thomas Harrington, MD.

More About Giant Cell Arteritis and Polymyalgia Rheumatica

What is giant cell arteritis? temporal arteritis?

Arteritis is a condition in which the arteries swell. Arteries are blood vessels that carry oxygen through the body from the heart.

Giant cell arteritis, or GCA, can occur in the arteries of the arms, upper body and neck. However, it usually affects the arteries that are above and in front of the ears on both sides of the head. This type of GCA is also sometimes called the temporal arteritis. Headache is the most common symptom. However, some patients might experience pain while chewing, blurred or reduced vision, or even blindness in one or both eyes.

Often, a biopsy of the temporal artery is needed to confirm the diagnosis. For this biopsy, a small piece of the temporal artery is removed and looked at under a microscope.

What is polymyalgia rheumatica?

Polymyalgia rheumatica (say: pol-lee-my-al-jah roo-matt-tick-ah), or PMR, is a condition in which the muscles inyour neck, shoulders, hips and thighs become swollen. This causes stiffness and aching in the neck, shoulders, hips and thighs.

A physical exam and blood tests are needed to find out if you have this condition.

How are GCA and PMR related?

About 15% of people with PMR have GCA, and about half of people with GCA have PMR. They can have these diseases at the same time, or CGA can develop after PMR.

What causes these conditions?

No one knows what causes GCA or PMR. Immune system problems and aging are possible factors. A physical exam and blood tests are needed to find out if you have this condition.

Who gets these conditions?

You are more likely to develop GCA and PMR is you are older than 50 years of age. They are most common in women between 70 and 80 years of age.

>> Read more and updates at FamilyDoctor.org, published by American Academy of Family Physicians

>> Questions and Answers about Polymyalgia Rheumatica and Giant Cell Arteritis (National Institute of Arthritis and Musculoskeletal and Skin Diseases)

>> Polymyalgia Rheumatica (Mayo Foundation for Medical Education and Research)

>> Polymyalgia Rheumatica (American College of Rheumatology) Also available in Spanish

Editor’s Notes:

About Geisinger Health System

Founded in 1915, Geisinger Health System (Danville, PA) is one of the nation's largest integrated health services organizations. Serving more than two million residents throughout central and northeastern Pennsylvania, the physician-led organization is at the forefront of the country's rapidly emerging electronic health records movement. Geisinger is comprised of two medical center campuses, three hospitals, a 720-member group practice, a not-for-profit health insurance company and the Geisinger Center for Health Research—dedicated to creating innovative new models for patient care, satisfaction and clinical outcomes. For more information, visit www.geisinger.org

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