Alzheimer's & Mental Health News for Senior Citizens

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Elderly show slower mental decline with more protein in brain

Cognitive decline about 50% slower for those with most protein from BDNF gene expression

human head with colorful depection of parts in brain Feb.9, 2016 - Elderly people with higher amounts of a key protein in their brains also had slower decline in their memory and thinking abilities than people with lower amounts of protein from the gene named "brain-derived neurotrophic factor," or BDNF, says a new study published online in Neurology.

 “This relationship was strongest among the people with the most signs of Alzheimer’s disease pathology in their brains,” said study author Aron S. Buchman, MD, of Rush University Medical Center in Chicago and a member of the American Academy of Neurology.

“This suggests that a higher level of protein from BDNF gene expression may provide a buffer, or reserve, for the brain and protect it against the effects of the plaques and tangles that form in the brain as a part of Alzheimer’s disease.”

For the study, 535 people with an average age of 81 were followed until death, for an average of six years.

They took yearly tests of their thinking and memory skills.


After death, a neurologist reviewed their records and determined whether they had


         some memory and thinking problems called mild cognitive impairment or

         no thinking and memory problems.

Autopsies were conducted on their brains after death, and the amount of protein from BDNF gene expression in the brain was then measured.

The participants were part of the Rush Memory and Aging Project and the Religious Orders Study.

The rate of cognitive decline was about 50 percent slower for those in the highest 10 percent of protein from BDNF gene expression compared to the lowest 10 percent.

The effect of plaques and tangles in the brain on cognitive decline was reduced for people with high levels of BDNF.

In the people with the highest amount of Alzheimer’s disease hallmarks in their brains, cognitive decline was about 40 percent slower for people with the highest amount of protein from BDNF gene expression compared to those with the lowest amount.

On average, thinking and memory skills declined by about 0.10 units per year on the tests. Higher levels of protein from BDNF gene expression reduced the effect of plaques and tangles in the brain on cognitive decline by 0.02 units per year.

The researchers found that the plaques and tangles in the brain accounted for 27 percent of the variation in cognitive decline, demographics accounted for 3 percent and BDNF accounted for 2 percent.

Study on Increasing BDNF in Elderly with Exercise

A study on the effect of physical exercise on the peripheral levels of BDNF in elderly individuals was reported in the Archives of Gerontology and Geriatric, Volume 56, Issue 1, Jan. & Feb. 2013, Pages 10-15. Click to Abstract

Five out of six studies reported a significantly higher BDNF response to aerobic acute exercise and to aerobic or strength training program in healthy elderly and elderly with different pathologies.

The researchers concluded it was not possible to establish a recommendation protocol for the type and intensity of physical exercise required to produce an increase in levels BDNF.

However, physical exercise, particularly, moderate-intensity exercises seem to be more effective to promote increase in the peripheral levels of BDNF in the elderly.

Exercise has been shown to increase levels of BDNF in the blood, but that the relationship between BDNF protein levels in the blood and in the brain is not clear, according to an accompanying editorial by Michal Schnaider Beeri, PhD, of the Icahn School of Medicine at Mount Sinai in New York.

“More research is needed to confirm these findings, determine how this relationship between protein produced by BDNF gene expression and cognitive decline works and see if any strategies can be used to increase BDNF in the brain to protect or slow the rate of cognitive decline,” said Buchman.

He also noted that the study does not prove that BDNF is the cause of a slower rate of cognitive decline; further work is needed to determine if activities which increase brain BDNF gene expression levels protect or slow the rate of cognitive decline in old age.

The study was supported by the National Institutes of Health, Illinois Department of Public Health and the Robert C. Borwell Endowment Fund.

The American Academy of Neurology, an association of 30,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy.

>> For more about this brain BDNF gene expression at the National Library of Medicine

>> Neurology is the medical journal of the American Academy of Neurology and this report was published online in the January 27, 2016 issue.

>> For more information about the American Academy of Neurology, visit or find more on Facebook, Twitter, Google+ and YouTube


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