Faster brain ventricle enlargement marker for
cognitive decline; first study to look at impact of less sleep
2, 2014 The less older people sleep, the faster their brains age,
according a new study. The researchers see their discovery as opening
the door for new studies on sleep loss and its contribution to cognitive
decline in seniors, including dementia.
The Duke-NUS Graduate Medical School Singapore
(Duke-NUS) researchers say previous research has examined the impact of
sleep duration on cognitive functions in older adults. Though faster
brain ventricle enlargement is known as a marker for cognitive decline
and the development of neurodegenerative diseases such as Alzheimer's,
the effects of sleep on this marker have never been measured.
The Duke-NUS study examined the data of 66 older
Chinese adults, from the Singapore-Longitudinal Aging Brain Study.
Participants underwent structural MRI brain scans measuring brain volume
and neuropsychological assessments testing cognitive function every two
years. Additionally, their sleep duration was recorded through a
Those who slept fewer hours showed evidence of
faster ventricle enlargement and decline in cognitive performance.
"Our findings relate short sleep to a marker of
brain aging," said Dr. June Lo, the lead author and a Duke-NUS Research
"Work done elsewhere suggests that seven hours a
day for adults seems to be the sweet spot for optimal performance on
computer based cognitive tests. In coming years we hope to determine
what's good for cardio-metabolic and long term brain health too," added
Professor Michael Chee, senior author and Director of the Centre for
Cognitive Neuroscience at Duke-NUS.
The research was published yesterday in the journal
The study was supported by funding from the
Biomedical Research Council, Singapore and the Singapore National
Research Foundation under its STaR Investigator Award administered by
the Singapore Ministry of Health's National Medical Research Council.
The Singapore-Longitudinal Aging Brain Study
(started in 2005) follows a cohort of healthy adults of Chinese
ethnicity aged 55 years and above. This study is one of the few in Asia
that tracks the brain structures and cognitive functions of older adults
Data collected by Lumosity, an online
brain-training program, suggests that self-reported sleep duration of
seven hours is associated with the best cognitive test scores in over
150,000 adults. As of now it is unknown if this amount of sleep is
optimum for cardio metabolic and long-term brain health.
The ventricular system of the brain has four
ventricles cavities filled with cerebrospinal fluid. The system has
a lateral ventricle on each side of the brain and a third and fourth
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