SeniorJournal.com - Daily News for Senior Citizens

  FRONT PAGE Aging • Health • Alzheimer's - Mental • Nutrition • Medicare & Medicaid Politics  • Fitness  • Social Security • Alerts • Sex Health • Features • Retirement  Elder Care  >Search  >Senior Links

[NavBar.htm]

Senior Journal: Today's News and Information for Senior Citizens & Baby Boomers

More Senior Citizen News and Information Than Any Other Source - SeniorJournal.com

• Go to Alzheimer's, Dementia & Mental Health or More Senior News on the Front Page

 
 

E-mail this page to a friend!

Alzheimer's, Dementia & Mental Health

Seniors with Less Education and Lower Levels of Biomarker Suffer Greater Cognitive Decline

'To identify those at risk of dementia, biomarkers like plasma beta-amyloid level that are relatively easy to obtain and minimally invasive could be useful'

Jan. 18, 2011 - Older adults without dementia and with lower levels in blood plasma of the biomarkers beta-amyloid 42/40 (protein fragments) had an increased rate of cognitive decline over a period of 9 years, according to a study in the January 19 issue of the Journal of the American Medical Association (JAMA). They also found this relationship stronger among individuals with less education and lower levels of literacy.

 

Related Stories

 

 

Senior Citizens with High Levels of ‘Good’ Cholesterol at Lower Risk of Alzheimer’s

About 1% of senior citizens age 65-69 have Alzheimer’s, increases to 60% over age 95, but study says high HDL cholesterol signals decreased risk of possible Alzheimer's - Dec. 13, 2010


Regular Consumption of High Cholesterol Diet May Lead to Alzheimer’s Disease

New study used rats to show brain damage produced from 5% cholesterol-enriched diet

Nov. 24, 2010


Small Amounts of Albumin in Urine Signals Rapid Mental Decline in Older Women

Study shows cognitive decline at a rate 2 to 7 times faster than that attributed to aging alone - suggest testing

Nov. 21, 2010


Pericyte Brain Cells Found to be Possible Key Players in Alzheimer’s, Other Diseases

Pericyte in a surprising new role as a key player shaping blood flow in the brain and protecting sensitive brain tissue from harmful substances

Nov. 17, 2010


Eating Beets Is A Safeguard Against Dementia Developing As Senior Citizens Age

Specialists in healthy foods for senior citizens say beet juice increases blood flow to brain

Nov. 8, 2010


Read the latest news on Alzheimer's, Dementia & Mental Health

 

An estimated 36 million people currently have dementia, with the prevalence expected to double every 20 years, according to background information in the article.

"Thus, biomarkers to identify elderly persons at risk of developing dementia could be useful for early prevention, if and when such interventions are available, and treatment," the authors write.

"Lower plasma beta-amyloid 42 and 42/40 levels have been associated with incident dementia, but results are conflicting and few have investigated cognitive decline among elders without dementia."

The study to investigate the association between plasma beta-amyloid 42 and 42/40 levels and cognitive decline in a large group of community-dwelling older adults without dementia, was conducted by Kristine Yaffe, M.D., of the University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, and colleagues.

They also examined whether measures of cognitive reserve, as indicated by levels of education and literacy attained, modified the association of plasma beta-amyloid level with cognitive decline.

The analysis included 997 black and white community-dwelling older adults who were enrolled in the Health ABC Study, a prospective observational study begun in 1997-1998 with 10-year follow-up in 2006-2007.

The study participants had the following characteristics:
   ● average age was 74 years;
   ● 55.2 percent (550) were female; and
   ● 54 percent (538) were black.

Measures of beta-amyloid 42 and 42/40 and cognitive function (via Modified Mini-Mental State Examination) were obtained.

The researchers found that low beta-amyloid 42/40 level was associated with greater cognitive decline over 9 years. After adjustment for several factors, the results remained statistically significant.

There was also a significant association between plasma beta-amyloid 42 levels and cognitive decline. There was no association between plasma beta-amyloid 40 levels and baseline cognitive function or decline.

Also, cognitive reserve measures modified the association between beta-amyloid 42/40 level and cognitive decline. Older adults with low reserve (as measured by less than a high school diploma or sixth-grade or lower literacy) had an even greater association with beta-amyloid 42/40 level, whereas those with high reserve had less association.

"These results are important, as the prevalence of cognitive impairment is increasing exponentially and prevention will be crucial. To identify those at risk of dementia, biomarkers like plasma beta-amyloid level that are relatively easy to obtain and minimally invasive could be useful,” the author’s write.

“In addition, our finding of an interaction of cognitive reserve with the association of plasma beta-amyloid level and cognitive decline could have public health importance because it may suggest pathways for modifying beta-amyloid effects on cognition," such as with cognitive activity or ongoing education, according to the study.

"Future studies should further explore the use of plasma beta-amyloid as a biomarker, assess the mechanisms by which cognitive reserve modifies this association, and determine whether increasing cognitive reserve through interventions can reduce the risk of Alzheimer disease."

Editorial: Mapping Out Biomarkers for Alzheimer Disease

"Of interest in relation to the study by Clark et al is that the relationship of beta-amyloid 42/40 and cognitive decline was modified by cognitive reserve, further evidence that for Alzheimer disease, the presence of pathology is not the whole story,” says an editorial in the same JAMA issue.

“The most important message from this and similar studies is that differences in proteins and peptides can be found in peripheral fluids years before clinical onset of dementia."

The editorial was by Monique M. B. Breteler, M.D., Ph.D., of Erasmus MC, University Medical Center Rotterdam, the Netherlands, and the German Center for Neurodegenerative Diseases, Bonn, Germany.

Financial Relief for Volkswagen Diesel Owners

You may be eligible for money damages if you owned or leased one of these VW, Porsche or Audi vehicles.

In the major scandal of 2015, Volkswagen cheated you and the world. They rigged diesel emission controls so you, nor regulators, would know how much pollution their cars were adding to our environment.

They were caught and have reserved $7.3 billion to help "make it right" with victims.

If you owned or leased one of these vehicles, contact us now.

 Beth Janicek, Board Certified Personal Injury Attorney Janicek Law attorneys are actively pursuing these cases against VW. Do Not Wait...

Janicek Law Firm, PC

Free Consultation

(Call toll free)

1-877-795-3425 or Email

Vehicles Involved

VW Jetta (2009–2015)

VW Jetta SportWagen (2009–2014)

VW Golf (2010-2015)

VW Golf SportWagen (2015)

VW Beetle (2012–2015)

VW Passat (2012-2015)

Audi A3 (2010-2015)

VW Touareg (2009–2016)

Porsche Cayenne (2015)

Audi A6, A7, A8, Q5 Quattro (2016)

 

Search for more about this topic on SeniorJournal.com

Google Web SeniorJournal.com

Keep up with the latest news for senior citizens, baby boomers

Click to More Senior News on the Front Page

Copyright: SeniorJournal.com

     Back to Top

 

Published by New Tech Media - www.NewTechMedia.com

Other New Tech Media sites include CaroleSutherland.com, BethJanicek.com, SASeniors.com, DrugDanger.com, etc.