Mayo Clinic Links Common Blood Pressure Drug to Severe GI Problems
Patients in clinical trial taking Olmesartan (Brenicar) had symptoms of celiac disease - video
discussion below news story
21, 2012 - Mayo Clinic researchers have discovered an association between a commonly prescribed blood pressure drug, Olmesartan (brand name:
Benicar), and severe gastrointestinal issues such as nausea, vomiting, diarrhea, weight loss and electrolyte abnormalities - symptoms common
among those who have celiac disease. The findings are published online today in the medical journal Mayo Clinic Proceedings.
Mayo Clinic physicians treated 22 patients with symptoms similar to celiac disease, including intestinal inflammation and
abnormalities from 2008-2011. Patients came from 17 states, and some had been diagnosed with celiac disease.
They had chronic diarrhea and weight loss; the median weight loss was 39 pounds, and one patient lost 125 pounds.
Fourteen of the 22 were hospitalized because of the severity of their symptoms. When given a blood test, however, these patients didn't come
back with results typical of celiac disease. They also didn't respond to treatments such as gluten-free diets.
After examining their medications, Mayo Clinic gastroenterologist Joseph Murray, M.D., pulled several of the patients off
Olmesartan. Their symptoms dramatically improved. Eventually, all 22 were taken off the drug, and all showed improvement. Eighteen of the 22
patients had intestinal biopsies after stopping the medication and showed improvement.
"We thought these cases were celiac disease initially because their biopsies showed features very like celiac disease,
such as inflammation," says Dr. Murray, the lead author. "What made them different was they didn't have the antibodies in their blood that are
typical for celiac disease."
(Watch video of Dr. Murray below news story)
Olmesartan - prescribed for the treatment of hypertension, or high blood pressure - works by blocking substances that
tighten blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently, according to the U.S. National Library on
"Olmesartan is also sometimes used to treat congestive heart failure (condition in which the heart is unable to pump
enough blood to the rest of the body) and diabetic nephropathy (kidney disease in people with diabetes and high blood pressure)," the NLM
"It's really an awareness issue. We want doctors to be aware of this issue, so if they see a patient who is having this
type of syndrome -- they think about medications as a possible association," Dr. Murray says. "We've reported an association. What needs to be
known next is the science to understand why there is such an association."
The investigators were supported in part by the National Institutes of Health, the American College of Gastroenterology
Junior Faculty Development Award, the Swedish Society of Medicine, the Swedish Research Council and the Fulbright Commission.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life.
For more information, visit
Safety Alert on Olmesartan in 2011
>> More on Olmesartan at National Library of Medcine
>> Choosing medicine for high blood pressure -
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