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Botox Substitute Without Needles May Be on the Way
Scientist find success with skin absorption of oat
beta glucan
Sept. 29, 2005 – The battle against the wrinkles
and lines of aging skin has received a scientific boost, thanks to an
innovative study that is the first to show that oat beta glucan can
penetrate the skin despite years of doctors and scientists believing
that the large molecule was too big. Beta glucan has been considered
helpful in healing wounds and smoothing skin, but this discovery can
enhance its use and possibly its use as an alternative to Botox.
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The study was done in part by a University of
Alberta spin-off company and dispels the hard-held belief about the
natural ingredient, beta glucan. The study, published in the current
issue of International Journal of Cosmetic Science, is the first to show
that oat beta glucan can penetrate the skin.
The finding is significant, not only in the
treatment of skin disorders and removing fine lines and wrinkles but in
the promotion of wound healing and reduction in scaring following
surgical procedures, says Dr. Mark Redmond, president and CEO of Ceapro
Inc, a spin-off company formed in the late 1980s to commercialize
technology from the University of Alberta's faculties of pharmacy and
medicine for the treatment of cold sores.
Beta-glucan is the soluble fiber found in the cell
walls of oat kernels. Oat has a long history of safe use in providing
fast, temporary relief of itching and pain associated with minor skin
irritations, has reported to improve the appearance of smoother skin and
has helped wound healing. But it has been long believed that such a
large molecule as beta glucan was too big to penetrate the skin.
In this paper, Redmond and his co-authors describe
using beta glucan-specific tracking dyes to show the skin penetration
did take place.
"Interestingly, the glucan penetrates in the same
way that water penetrates a brick wall--it does not go through the
brick, it goes through the concrete binding the bricks together," says
Redmond.
"As a result of our study, we now know that glucan
works through the inter-cellular lipid matrix, or the cells' cement, to
enter the lower levels of the skin. Of medical significance is the fact
that beta glucan creams promote wound healing and reduction in scaring
following surgical procedures."
The research team, made up of Redmond, Ravi Pillai
and Joachim Roding both from Symrise, then measured the depth of the
skin that the glucan penetrated. Photographs show the actual reduction
of wrinkles and consumers should expect to see similar results on
themselves in as little as ten days, says Redmond.
Beta glucan is already used in a number of products
available to consumers including brand name products from Johnson and
Johnson and Schering Plough.
"The proof that we provide in this paper and other
research that we have conducted is that glucan can have a specific and
measurable effect on skin beyond making you look good and feeling
great," says Redmond. "We also have indications that a number of
applications in cosmetics are in the works to use glucan as the
non-invasive alternative to Botox for those who are afraid of needles."
Ceapro has also discovered that beta glucan can be
used as a transdermal delivery system to feed drugs and other compounds
into the skin. This development may lead to new and better ways of
delivering such medicines as antihistamines and pain relievers.
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