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Aging & Longevity

Add a little protein for more energy and live longer

Research highlights importance of energy regulation to long, healthy life

c. elegans roundworm in action

c. elegans roundworm. More info below news report.

Feb. 26, 2016 – If a senior citizen wants to extend their life by 25 percent – say from age 80 to 100 – all one needs to do is add more of a protein called arginine kinase-1 to their system. Well, you may also need to be a C. elegans roundworm, because that’s where scientists made this discovery that they say could extend longevity.

The findings, published yesterday in Cell Reports, do expand what we know about the aging process and may lead to new ways to delay the onset of human age-related diseases such as cancer and neurodegenerative diseases.

This new research from the Sanford Burnham Prebys Medical Discovery Institute (SBP), scientists have identified this protein that can extend the natural lifespan of C. elegans, a microscopic roundworm commonly used for research on aging and longevity.

"We found that longevity can be extended by increasing the amount of a protein called arginine kinase-1 (ARGK-1)," said Philip McQuary, Ph.D., first author of the study and a former graduate student in the laboratory of Malene Hansen, Ph.D., associate professor in the Development, Aging, and Regeneration Program at SBP.

"ARGK-1 maintains ATP availability within cells, and we suspect that increased levels trigger a fuel sensor, regulating energy homeostasis and extending lifespan."

The research team identified ARGK-1 by comparing protein levels in normal worms to those in worms lacking S6 kinase (S6K), a genetic change that extends worm lifespan by at least 25%.

Reduction of S6K proteins also extends lifespan significantly in several other organisms, including laboratory mice, showing that this pathway that controls aging is evolutionarily conserved.

"ARGK-1 caught our attention because levels in S6K mutant worms were more than 30 times higher compared to normal worms," said McQuary. "When we created normal worms that overexpressed ARGK-1, they also lived significantly longer, meaning that ARGK-1 on its own can extend life."

ARGK-1 and its mammalian equivalent, creatine kinase, are enzymes that transport energy in the form of phosphoarginine or phosphocreatine to various locations within cells. The research team found that, as in worms, creatine kinase levels are increased in the brains of mice lacking a similar S6K protein.

"Interestingly, supplements with creatine, the substrate for creatine kinase, have been found to improve health and longevity in mice and possibly provide beneficial effects to humans with Parkinson's disease, suggesting a potential role for these enzymes in aging and age-related diseases," added McQuary.

"Sorting out which cell functions are protected will be crucial for understanding exactly how ARGK-1 supports longevity in C. elegans, and potentially in other organisms as well."

 

"Our main goal in studying aging is not to find ways to extend human lifespan, but to understand the processes by which our cells and tissues become less functional over time," explained Hansen.

“Such insight might allow us to develop better preventive care that improves overall health at advanced ages, or interventions that can slow or perhaps even prevent the progression of diseases associated with aging.

"For example, in cancer, some tumors highly activate S6K to feed tumor growth.

"Further work to understand the relationship between creatine kinase and S6K may lead to new avenues to pursue novel drugs for age-related diseases, including cancer."

This research was performed in collaboration with the Buck Institute for Research on Aging, the Scripps Research Institute, and the University of Washington, and funded by the National Institutes of Health, the American Federation for Aging Research, the Glenn Foundation for Medical Research, and the Ellison Medical Foundation.

About Sanford Burnham Prebys Medical Discovery Institute

Sanford Burnham Prebys Medical Discovery Institute (SBP) is an independent nonprofit research organization. For more information, visit SBPdiscovery.org. The Institute can also be found on Facebook at facebook.com/SBPdiscovery and on Twitter @SBPdiscovery.

About Worms:

Caenorhabditis elegans is a free-living, transparent nematode (roundworm), about 1 mm in length, which lives in temperate soil environments. C. elegans is unsegmented, vermiform, and bilaterally symmetrical, with a cuticle integument, four main epidermal cords and a fluid-filled pseudocoelomate cavity. Members of the species have many of the same organ systems as other animals. In the wild, they feed on bacteria that develop on decaying vegetable matter. More at Wikipedia

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