Senior Citizens Lose Ability to Distinguish Between Odors: Can Be Dangerous
Smells blending together pose hazards from poor nutrition, dangerous chemicals, researchers find
Nov. 10, 2011 Most senior citizens are aware that their sense of smell is not as good as it once was. A new study finds
older people beginning at about age 60 have difficulty in distinguishing specific smells. It is not a laughing matter, however. The
researchers say it puts senior citizens a greater risk from dangerous chemicals and poor nutrition.
"We found clear changes in olfactory sensory neuron responses to odors for those 60 and up," said Professor Diego
Restrepo, Ph.D., director of the Center for NeuroScience at the University of Colorado School of Medicine who led the researchers.
"When we presented two different odors to the olfactory sensory neurons of younger people they responded to one or the
other. The sensory neurons from the elderly responded to both. This would make it harder for the elderly to differentiate between them."
According to the study published in the latest issue of Neurobiology of Aging, those losing their sense of smell
are at a higher risk of malnutrition since taste and smell are closely related, they may also be unable to detect spoiled food, leaking gas or
Researchers looked at 440 subjects in two age groups those 45- years-old and younger and those 60 and over. Their
olfactory sensory neurons (OSNs) were tested for their responses to two distinct odors as well as subsets of those odors.
Restrepo wanted to determine if age-related differences in the function of OSNs might contribute to an impairment of the
sense of smell. For this, in a collaboration with Monell Chemical Senses Center in Philadelphia, researchers biopsied cells from both age
"Whereas cells from younger donors were highly selective in the odorants to which they responded, cells from older donors
were more likely to respond to multiple odor stimuli suggesting a loss of specificity," the study said.
The scientists had expected to find less OSNs in older subjects and they thought the neurons would be less likely to
respond to stimuli. In fact, they found as many neurons in the old as the young but those over 60 could not differentiate between two odors,
they blended together.
The study suggests that changes in nose and the brain contribute to smell loss in the elderly, Restrepo said.
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